The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases

Eisenstein, Anna; Patterson, Shenia; Ravid, Katya

doi:10.1002/jcp.25043

Cited by 29 publications

(21 citation statements)

References 97 publications

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“…Many cardiovascular diseases have atherosclerosis as an aetiological factor. In particular, endothelial dysfunction with the accumulation and oxidation of LDL leads to an increase in foam cells (Eisenstein et al , ). The role of adenosine receptors in the development of atherosclerosis has been investigated.…”

Section: Pathological Role Of Adenosine In Inflammatory Conditionsmentioning

confidence: 99%

Pathological overproduction: the bad side of adenosine

Borea

Gessi

Merighi

et al. 2017

British J Pharmacology

101

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Adenosine is an endogenous ubiquitous purine nucleoside, which is increased by hypoxia, ischaemia and tissue damage and mediates a number of physiopathological effects by interacting with four GPCRs, identified as A , A , A and A . Physiological and acutely increased adenosine is mostly associated with beneficial effects that include vasodilatation and a decrease in inflammation. In contrast, chronic overproduction of adenosine occurs in important pathological states, where long-lasting increases in the nucleoside levels are responsible for the bad side of adenosine associated with chronic inflammation, fibrosis and organ damage. In this review, we describe and critically discuss the pathological overproduction of adenosine and analyse when, where and how adenosine exerts its detrimental effects throughout the body.

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Section: Pathological Role Of Adenosine In Inflammatory Conditionsmentioning

confidence: 99%

Pathological overproduction: the bad side of adenosine

Borea

Gessi

Merighi

et al. 2017

British J Pharmacology

101

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“…A 2B AR may contribute to the pathogenesis of atherosclerosis. During hypoxia, A 2B AR promoted HIF-1α-induced differentiation of macrophages and foam cells (FC) in preventing atherosclerosis plaque formation [245]. Administration of BAY 60-6853 altered the lipid profile and decreased atherosclerosis in mice [189].…”

Section: A 2b Ar In Cardiovascular Systemsmentioning

confidence: 99%

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Effendi

Nagano

Kobayashi

et al. 2020

Cells

122

103

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Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as A1AR, A2AAR, A2BAR, and A3AR, which are the center of cAMP signal pathway-based drug development. Several types of agonists, partial agonists or antagonists, and allosteric substances have been synthesized from these receptors as new therapeutic drug candidates. Research efforts surrounding A1AR and A2AAR are perhaps the most enticing because of their concentration and affinity; however, as a consequence of distressing conditions, both A2BAR and A3AR levels might accumulate. This review focuses on the biological features of each adenosine receptor as the basis of ligand production and describes clinical studies of adenosine receptor-associated pharmaceuticals in human diseases.

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“…disease [13], coronary blood flow [14], chronic heart failure [15], atherosclerosis, and dyslipidemia [16].…”

Section: Study Populationmentioning

confidence: 99%

“…A recent review highlighted that the ADORA gene members are modulators of lipid availability [12]. The physiological role of the ADORAs has been reported to be associated with lipid-related diseases, including cardiovascular disease [13], coronary blood flow [14], chronic heart failure [15], atherosclerosis, and dyslipidemia [16].…”

Section: Introductionmentioning

confidence: 99%

Effects of Coffee Intake on Dyslipidemia Risk According to Genetic Variants in the ADORA Gene Family among Korean Adults

et al. 2020

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Current evidence on the effects of coffee intake on cardiovascular diseases is not consistent, in part contributed by the genetic variability of the study subjects. While adenosine receptors (ADORAs) are involved in caffeine signaling, it remains unknown how genetic variations at the ADORA loci correlate the coffee intake with cardiovascular diseases. The present study examined the associations of coffee intake with dyslipidemia risk depending on genetic variants in the ADORA gene family. The study involved a population-based cohort of 4898 Korean subjects. Consumption of more than or equal to a cup of coffee per day was associated with lower dyslipidemia risk in females carrying the ADORA2B minor allele rs2779212 (OR: 0.645, 95% CI: 0.506–0.823), but not in those with the major allele. At the ADORA2A locus, male subjects with the minor allele of rs5760423 showed instead an increased risk of dyslipidemia when consuming more than or equal to a cup of coffee per day (OR: 1.352, 95% CI: 1.014–1.802). The effect of coffee intake on dyslipidemia risk differs depending on genetic variants at the ADORA loci in a sex-specific manner. Our study suggests that a dietary guideline for coffee intake in the prevention and management of dyslipidemia ought to consider ADORA-related biomarkers carefully.

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The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases

Cited by 29 publications

References 97 publications

Pathological overproduction: the bad side of adenosine

Pathological overproduction: the bad side of adenosine

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Effects of Coffee Intake on Dyslipidemia Risk According to Genetic Variants in the ADORA Gene Family among Korean Adults

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