The many facets of Notch ligands

D’Souza, Brendan; Miyamoto, Alison; Weinmaster, Gerry

doi:10.1038/onc.2008.229

Cited by 397 publications

(337 citation statements)

References 238 publications

(337 reference statements)

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“…Jagged and DLL are both capable of inducing the same canonical Notch signaling pathway. However, the different ligands do possess unique functions, although the underlying mechanisms are not understood [17].…”

Section: Notch Ligands Are Alternative Signals For T H 1/t H 2 Differmentioning

confidence: 99%

How are TH1 and TH2 effector cells made?

Amsen

Spilianakis²,

Flavell

2009

Current Opinion in Immunology

142

128

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SummaryDifferentiation of T H 1 and T H 2-effector cells proceeds through several phases: First, naïve CD4 + precursor cells are instructed to differentiate as appropriate to optimally fight the infectious threat encountered. This process is governed by the IL12 and IL4 cytokines, as well as by signaling through the Notch receptor. In response to these signals, transcription is initiated of lineage specific genes including the Ifnγ and Il4 genes as well as of genes encoding transcriptional regulators, such as Tbet and Gata3. The respective differentiation programs are reinforced by both positive and negative feedback mechanisms. Furthermore, epigenetic modifications of the lineage specific genes result in the emergence of regulatory elements, which control high level lineage restricted expression by both intra-and interchromosomal associations. Together, these mechanisms ensure stable inheritance of the differentiated fate in the numerous progeny of the original naïve CD4 + T cells.

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Section: Notch Ligands Are Alternative Signals For T H 1/t H 2 Differmentioning

confidence: 99%

How are TH1 and TH2 effector cells made?

Amsen

Spilianakis²,

Flavell

2009

Current Opinion in Immunology

142

128

View full text Add to dashboard Cite

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“…9,55 Membrane-associated receptors and integrins are numerous, and their role in hematopoiesis is a field of investigation under constant flux that has regularly been reviewed in detail. 51,[56][57][58][59][60][61][62][63][64][65][66][67][68][69][70] We will briefly highlight major points of interest for several of the most studied receptors below and in Table 1.…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

“…Notch signaling plays an active role in tissue homeostasis, with initially studies first describing its role in embryonic development. 65,74,75 In humans, Delta-like and/or Jagged ligands bind to four Notch receptors, and studies suggest that Notch activation may to play some role in HSCs maintenance and/or expansion. 51,65 In fact, recent work has found that Notch activation can be utilized to expand primitive HSCs for transplantation.…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

“…65,74,75 In humans, Delta-like and/or Jagged ligands bind to four Notch receptors, and studies suggest that Notch activation may to play some role in HSCs maintenance and/or expansion. 51,65 In fact, recent work has found that Notch activation can be utilized to expand primitive HSCs for transplantation. 76 However, it remains unclear if Notch is required for perpetual maintenance of these cells.…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

“…76 However, it remains unclear if Notch is required for perpetual maintenance of these cells. 65,74,75 WNT signaling may also play some role in promoting the expansion of primitive HSCs and has been implicated in HSCs selfrenewal. 75 Although Notch and WNT pathways represent the "state-of-the-art" in our understanding of how membrane receptors influence hematopoiesis, many aspects of these receptors' biology remains unknown, highlighting the need for additional studies.…”

Section: Regulation Of Expression Via Cell Membrane Proteinsmentioning

confidence: 99%

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Gene expression changes in normal haematopoietic cells

Lionberger¹,

Stirewalt²

2009

Best Practice & Research Clinical Haematology

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The complexity of the healthy hematopoietic system is immense, and as such, one must understand the biology driving normal hematopoietic expression profiles when designing experiments and interpreting expression data that involves normal cells. This chapter seeks to present an organized approach to the use and interpretation of gene profiling in normal hematopoiesis and broadly illustrates the challenges of selecting appropriate controls for high-throughput expression studies.

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Signalling via Single‐Pass Transmembrane Proteins

Pahl

Askinazi

Hamilton

et al. 2013

Encyclopedia of Life Sciences

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Single‐pass transmembrane proteins (TM1) are a diverse group of proteins characterised by a single transmembrane domain. In total, the authors found approximately 1300 TM1 proteins in the human genome, most of which have characterised functions. The extracellular domains of these proteins range up to 22 000 amino acids with an average size being six times larger than intracellular domains. This suggests that these proteins have evolved the capacity to bind a wide array of ligands and substrates. Consequently, these proteins are involved in many processes, such as adhesion, migration, growth and cell death, among others. Although many act as receptors for first messengers (extracellular signalling molecules), they can also serve as ligands, adaptors, proteases and coreceptors. Herein, the authors provide a broad overview of these different roles along with examples of their involvement in pathological and physiological situations. Key Concepts: Single‐pass transmembrane proteins participate in signalling in a variety of ways, either as ligands, receptors, enzymes coreceptors and/or adaptors. TM1 proteins appear to have undergone evolutionary expansion as a function of body plan complexity. The extracellular domains of TM1 proteins cluster well based on family, whereas the intracellular domains do not. TM1 proteins are adapted to bind very large substrates/ligands compared with other receptor families (ion channels and GPCRs). TM1 have roles in every organ system and are particularly important in the immune and nervous systems.

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The many facets of Notch ligands

Cited by 397 publications

References 238 publications

How are TH1 and TH2 effector cells made?

How are TH1 and TH2 effector cells made?

Gene expression changes in normal haematopoietic cells

Signalling via Single‐Pass Transmembrane Proteins

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