The many roles of microRNAs in brain tumor biology

Turner, Jay D.; Williamson, Richard A.; Almefty, Kaith K.; Nakaji, Peter; Porter, Randall; Tse, Victor; Kalani, M. Yashar S.

doi:10.3171/2009.10.focus09207

Cited by 63 publications

(40 citation statements)

References 76 publications

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“…Previous studies have demonstrated that single nucleotide polymorphisms (SNP) or mutations in miRNA sequences may affect cancer susceptibility by altering miRNA expression, maturation or miRNA-mRNA interaction (9,10). Aberrant miRNA expression has been consistently reported to be associated with oncogenesis (11,12) and the deregulated expression of miRNAs and their targets may result from functional polymorphisms in the miRNA sequence (13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Effect of a functional polymorphism in the pre-miR-146a gene on the risk and prognosis of renal cell carcinoma

Huang

Tian

et al. 2015

Molecular Medicine Reports

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Abstract. MicroRNAs (miRNAs) are non-coding RNAs that function as regulators of tumor suppressors and oncogenes. A G>C polymorphism (rs2910164) in the miR-146a precursor sequence leads to a functional change associated with a risk for various types of malignancy. The role of this single nucleotide polymorphism in the pathogenesis of renal cell carcinoma (RCC) has not yet been examined. The present study evaluated the association between rs2910164 genotypes and the risk and prognosis of RCC in a population comprised of 421 RCC cases and 432 controls. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for rs2910164 genotypes according to case status. Cox proportional hazards regression modeling was used to estimate hazards ratios and 95% CIs according to the genotypes among the RCC patients. It was found that the rs2910164 GG and GC genotypes were associated with an increased risk of RCC only in senior subjects (>57-years old; adjusted OR=1.59, 95% CI=1.04-2.43). Furthermore, the GC and GG genotypes were associated with a poorer survival rate among patients with RCC compared with the CC genotype (P=0.002). In conclusion, the observed association between the GG and GC genotype and poorer survival rate of RCC was at least partially mediated by the decreased expression of miR-146a.

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Section: Introductionmentioning

confidence: 99%

Effect of a functional polymorphism in the pre-miR-146a gene on the risk and prognosis of renal cell carcinoma

Huang

Tian

et al. 2015

Molecular Medicine Reports

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“…Discovery of the posttranscriptional modulation of gene expression via small RNAs has led to a huge number of publications in areas such as cancer and brain development (Fineberg et al 2009;Turner et al 2010) Expression levels on day 4 were significantly less than at any other day (a, b Bonferroni test; p \ 0.05). The DC t levels were subtracted from 10 so that higher values reflect higher expression.…”

Section: Discussionmentioning

confidence: 98%

Differential expression of microRNA-1 in dorsal root ganglion neurons

Bastian

Tam

Zhou

et al. 2010

Histochem Cell Biol

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Damage to sensory neurons induces neural repair, regrowth and hyperexcitability. The regulation of such responses to injury must be organized in some way by the neurons. Regulation can occur at the post-transcriptional level via microRNAs (miRNAs). miRNAs are small non-coding RNAs that influence the stability or translation of mRNAs and thereby regulate gene expression. Although nociceptive neurons show transcriptional and post-transcriptional regulatory mechanisms at many levels, miRNAs have not yet been systematically investigated in these neurons. Based on our preliminary array data we investigated the presence of miR-1 in dorsal root ganglion (DRG) neurons of mice and humans. We detected miR-1 in total RNA from human and mouse DRG and localised miR-1 in human and murine sensory neurons in situ. In Situ Hybridization detected miR-1 expression by nearly all DRG neurons. In vitro studies of enriched sensory neuron subpopulations from mouse DRG showed higher miR-1 expression levels in I-B4 negative neurons compared with I-B4 positive cells. Culturing of primary sensory neurons reduced the relative miR-1 expression levels independent of the presence or absence of laminin on the culture substrate. Transfection with a miR-1 mimic induced a massive increase in neuronal miR-1 associated with attenuated neurite outgrowth. This first description of miR-1 in sensory neurons including nociceptors suggests that miR-1 has a role in modulating neurite outgrowth.

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“…In contrast, medulloblastoma (MB) is the most common brain malignancy in children that arises from altered development of cerebellar progenitor cells [69]. MicroRNAs certainly play critical roles in cancer initiation, progression, and some of them could be considered as clinical biomarkers for cancer diagnosis, prognosis and prediction of therapeutic response [70]. Specifically, expression profiling studies have revealed extensive alteration of microRNAs in primary glioblastoma, suggesting that microRNAs may represent a new class of genes involved in …”

Section: Micrornas In Brain Tumor Developmentmentioning

confidence: 99%

MicroRNAs in neural cell development and brain diseases

Feng

2011

Sci. China Life Sci.

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MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation and/or promoting mRNA degradation. Importantly, biogenesis of microRNAs displays specific temporal and spatial profiles in distinct cell and tissue types and hence affects a broad spectrum of biological functions in normal cell growth and tumor development. Recent discoveries have revealed sophisticated mechanisms that control microRNA production and homeostasis in response to developmental and extracellular signals. Moreover, a link between dysregulation of microRNAs and human brain disorders has become increasingly evident. In this review, we focus on recent advances in understanding the regulation of microRNA biogenesis and function in neuronal and glial development in the mammalian brain, and dysregulation of the microRNA pathway in neurodevelopmental and neurodegenerative diseases. microRNAs, neuronal development, synaptic plasticity, oligodendroglial differentiation, brain tumor, neurodegenerative disorders Citation:Feng W, Feng Y. MicroRNAs in neural cell development and brain diseases.

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The many roles of microRNAs in brain tumor biology

Cited by 63 publications

References 76 publications

Effect of a functional polymorphism in the pre-miR-146a gene on the risk and prognosis of renal cell carcinoma

Effect of a functional polymorphism in the pre-miR-146a gene on the risk and prognosis of renal cell carcinoma

Differential expression of microRNA-1 in dorsal root ganglion neurons

MicroRNAs in neural cell development and brain diseases

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