2012
DOI: 10.1002/wrna.1118
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The many roles of the eukaryotic elongation factor 1 complex

Abstract: The vast majority of proteins are believed to have one specific function. Throughout the course of evolution, however, some proteins have acquired additional functions to meet the demands of a complex cellular milieu. In some cases changes in RNA or protein processing allow the cell to make the most of what is already encoded in the genome to produce slightly different forms. The eukaryotic Elongation Factor 1 (eEF1) complex subunits, however, have acquired such moonlighting functions without alternative forms… Show more

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Cited by 253 publications
(208 citation statements)
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“…Presumably these modifications reflect highly complex mechanisms of regulation in eukaryotes (Le Sourd et al, 2006;Sasikumar et al, 2012). Phosphorylation of elongation factors under photosynthetic control was not reported for Arabidopsis (Boex-Fontvieille et al, 2013).…”
Section: Eef1bmentioning
confidence: 93%
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“…Presumably these modifications reflect highly complex mechanisms of regulation in eukaryotes (Le Sourd et al, 2006;Sasikumar et al, 2012). Phosphorylation of elongation factors under photosynthetic control was not reported for Arabidopsis (Boex-Fontvieille et al, 2013).…”
Section: Eef1bmentioning
confidence: 93%
“…Seed endosperm of the maize opaque 2 mutant has increased levels of eEF1A from multiple genes and is associated with improved lysine content (Lopez-Valenzuela et al, 2003;Lopez-Valenzuela et al, 2004). Interestingly, eEF1A has functions and interactions outside of its role in translation includ-ing association with cytoskeleton (which may reflect an association of the translation process with cytoskeleton anchors), nuclear export, proteolysis, apoptosis and viral propagation (Browning, 1996;Sasikumar et al, 2012). This factor is also known to participate in processes including export of tRNAs from the nucleus and the targeting of damaged and misfolded proteins to the proteasome (Sasikumar et al, 2012).…”
Section: The Actors In Elongation Eef1amentioning
confidence: 99%
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