2020
DOI: 10.1186/s13045-020-00949-4
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The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Abstract: Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting AMPK signaling, a key singular node of cellular metabolism. … Show more

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Cited by 314 publications
(261 citation statements)
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References 285 publications
(378 reference statements)
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“…In this study, Wnt signaling was suppressed following treatment, possibly indicating that Wnt signaling was a critical target of the combination therapy. The Ras/RAF/MEK/ ERK signaling pathway is another best-defined pathway in cancer biology (38). ERKs belong to the MAPK family of kinases, which also comprise of p38MAPK and JNK (39).…”
Section: Discussionmentioning
confidence: 99%
“…In this study, Wnt signaling was suppressed following treatment, possibly indicating that Wnt signaling was a critical target of the combination therapy. The Ras/RAF/MEK/ ERK signaling pathway is another best-defined pathway in cancer biology (38). ERKs belong to the MAPK family of kinases, which also comprise of p38MAPK and JNK (39).…”
Section: Discussionmentioning
confidence: 99%
“…MAPK is a well-studied oncogenic pathway, which counts for nearly 40% of human cancer cases [66]. According to TCGA database, the CD274 mRNA level was significantly positively related to RAS-or MEK-activation scores in NSCLC patients [67].…”
Section: Mitogen-activated Protein Kinase (Mapk)mentioning
confidence: 99%
“…Here, MAPK signaling pathways were specially known to affect various diseases including tumorigenesis. 39 Taken together, the results of GO and KEGG pathway enrichments supported that all of the 20 predicted targets had the characteristics and functions as the therapeutic targets of sinomenine for treating breast cancer.…”
Section: Characteristics and Functions Of Predicted Targets For Treatmentioning
confidence: 73%