The Meiling Cu-polymetallic deposit is located in the Kalatag Cu metallogenic belt of the East Tianshan, Xinjiang, NW China. Multiple-stage hydrothermal activities have resulted in the silicification, chlorite alteration and sericite alteration in this deposit. At least three mineralization stages are recorded: (a) a phase comprising quartz-pyrite veining, (b) a quartz-chalcopyrite-pyrite-sphalerite phase and (c) a quartz-calcite phase, respectively. LA-ICP-MS zircon U-Pb dating yielded 302 ± 2.1 Ma for an orebearing quartz porphyry and 296 ± 3.2 Ma for a post-mineralization diorite porphyry dyke, respectively, indicating that the copper mineralization took place during the Late Carboniferous period (302-296 Ma). Fluid evolution during the three stages of mineralization was determined by a detailed fluid inclusion study: (a) Stage I fluids were trapped under two-phase conditions, as evidenced by the coexistence of vapour-rich (type II) inclusions (T h = 183-242 C, average salinity = 4.8 wt% NaCl equiv.), liquid-rich (type I) inclusions (T h = 171-259 C, average salinity = 5.3 wt% NaCl equiv.), and daughter-bearing (type III) inclusions (T h = 192-208 C, average salinity = 8.6 wt% NaCl equiv.). (b) Stage II fluid inclusions in quartz were also trapped under two-phase conditions (boiling), as identified by the coexistence of V-and Ltype fluid inclusions; L-type inclusions T h between 136 and 218 C (average = 189 C), with salinities of 2.2-7.6 wt% NaCl equiv. (average = 3.8 wt% NaCl equiv.). V-type inclusions homogenized temperatures between 153 and 226 C (average = 192 C), with salinities of 2.4-6.7 wt% NaCl equiv. (average = 3.5 wt% NaCl equiv.). (c) Stage III fluids are represented by inclusions in barren quartz-carbonate veinlets, characterized by homogenization temperatures ranging from 98 to 177 C (average = 135 C) and salinities between 0.5 and 3.2 wt% NaCl equiv. (average = 1.9 wt% NaCl equiv.). The initial hydrothermal fluids are characterized by low-intermediate temperature, low-salinity and near-neutral pH condition, belonging to a H 2 O-NaCl bearing hydrothermal system. The mineralization of the Meiling deposit occurred at a shallow