The marine secondary metabolites 2,4-dibromophenol and 2,4,6-tribromophenol differentially modulate voltage dependent ion currents in neuroendocrine (PC12) cells

Abstract

). The major contribution to calcium channel currents was mediated by L-type (67%) and N-type channels (30%) in PC12 cells; both bromophenols modulated both current types. Whole cell outward currents, mainly carried by potassium ions, were reduced by 2,4-DBP with a half-maximal concentration of 41 ± 9 M (S.D.) showing a Hill coefficient of 1.71 ± 0.31 (S.D.). 2,4,6-TBP showed a weak reduction of outward currents at high concentrations of 300 M. 2,4,6-TBP selectively decreased calcium entry via calcium channels as revealed in whole cell patch clamp experiments, whereas 2,4-DBP reduced both in-and outward currents.

Formation of Organobrominated Compounds in the Presence of Bromide under Simulated Atmospheric Aerosol Conditions

“…[22] For the purpose of this study, they are environmentally significant compounds because they are suspected endocrine disruptors. [23] Recent interest has been devoted to the formation of reactive halogen species in tropospheric aerosols [24][25][26] because of their involvement in the transformation of organic compounds in the gas phase, [27] on particles, and inside water droplets, [28] and because of the role they play in tropospheric ozone cycles [Eqs.…”

Non-target Screening of Organic Contaminants in Sediments from the Industrial Coastal Area of Kavala City (NE Greece)

“…Further on, trichloro-and pentachlorobenzenes, partially known as widely used agents in the technosphere, and the well-known flame retardant dibromophenol (Hassenkloever and Bickmeyer 2006) have been identified exclusively in sample S7 with only 1 to 27 ng/g. In the same sample (S7) as well as in a group of aquatic sediment samples from swales and canals around the fishery (T3, T4, and T5), trichlorobutanol was detected with relative high concentrations up to 320 ng/g.…”

Thermochemical study of three dibromophenol isomers

“…They are detected in the blood of humans and they may be the source of disturbance of the endocrine system caused by their influence on cellular calcium signaling in neuro-endocrine cells, as shown by Hassenklöver et al [12], or by binding to the estrogen receptor as shown by Olsen et al [14].…”

“…These bromophenols are likely biosynthesized from the organisms diet and can be detected in many kinds of seafood, as in bryozoans, sponges, crustaceans, polychaetes, mollusks, fish, and mammals [8][9][10]. The 2,4-and 2,6-dibromophenol have been identified as key flavor components in marine animals at suitable amounts [11,12]. In particularly, 2,4-dibromophenol is widely used in industry as flame retardants, biocides, and wood treatment agents, having toxic effects on living organisms [8,11,13].…”