After the COVID-19, the search for innovative organizational and occupational change are essential to the achievement of sustainable health and economic targets. Instead, to fight the pandemic, one of the remedies is precisely to isolate one's own. The treatment for the most serious infections is treated in hospital, with working hours and emotional loads, not previously known by doctors and nurses. The study's aim is to examine the various expectations and profiles of doctors and nurses during a pandemic. The study's aim is to identify, using a regression analysis, the elements that both concerned health workers and those who assisted in supporting and overcoming this extended crisis. The data analysis highlights the strategic significance of the organization in the sector, specifically in respect to structures and services. In the context of the complex health organization, the conclusions suggest possible activities to be performed in order to execute an organizational change.