The market trend analysis and prospects of cancer molecular diagnostics kits

Seo, Ju Hwan; Lee, Joon Woo; Cho, Daemyeong

doi:10.1186/s40824-017-0111-9

Cited by 9 publications

(6 citation statements)

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“…Risk assessment, early diagnosis, and prevention of disease, including for CRC, is critical for an effective reduction of mortality and increased quality of life; therefore, great effort has recently been put into advancing early cancer diagnosis, including the development of effective prediction models and in vitro diagnostics (IVD) 47,48 . Although several diagnostic models have been developed to predict CRC risk, models limited to primarily epidemiological data have shown relatively low discriminatory power, with AUCs ranging from 0.61 to 0.78 49,50 .…”

Section: Discussionmentioning

confidence: 99%

Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis

Yang

McDowell²,

Kim³

et al. 2019

Exp Mol Med

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Colorectal cancer (CRC) is the third most common form of cancer and poses a critical public health threat due to the global spread of westernized diets high in meat, cholesterol, and fat. Although the link between diet and colorectal cancer has been well established, the mediating role of the gut microbiota remains elusive. In this study, we sought to elucidate the connection between the gut microbiota, diet, and CRC through metagenomic analysis of bacteria isolated from the stool of CRC (n = 89) and healthy (n = 161) subjects. This analysis yielded a dozen genera that were significantly altered in CRC patients, including increased Bacteroides, Fusobacterium, Dorea, and Porphyromonas prevalence and diminished Pseudomonas, Prevotella, Acinetobacter, and Catenibacterium carriage. Based on these altered genera, we developed two novel CRC diagnostic models through stepwise selection and a simplified model using two increased and two decreased genera. As both models yielded strong AUC values above 0.8, the simplified model was applied to assess diet-based CRC risk in mice. Mice fed a westernized high-fat diet (HFD) showed greater CRC risk than mice fed a regular chow diet. Furthermore, we found that nonglutinous rice, glutinous rice, and sorghum consumption reduced CRC risk in HFD-fed mice. Collectively, these findings support the critical mediating role of the gut microbiota in diet-induced CRC risk as well as the potential of dietary grain intake to reduce microbiota-associated CRC risk. Further study is required to validate the diagnostic prediction models developed in this study as well as the preventive potential of grain consumption to reduce CRC risk.

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Section: Discussionmentioning

confidence: 99%

Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis

Yang

McDowell²,

Kim³

et al. 2019

Exp Mol Med

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“…Furthermore, repeated interventions are not feasible; thus, accurate monitoring of cancer evolution is not possible [ 90 ]. The detection of circulating cancer biomarkers through liquid biopsies offers a low-cost, simple, and non-invasive alternative to this problem [ 6 , 87 , 91 , 92 ]. In vivo imaging of cancer biomarkers is another possible alternative to tissue biopsy [ 93 ].…”

Section: Mip-based Cancer Diagnosismentioning

confidence: 99%

Molecularly imprinted polymers (MIPs): emerging biomaterials for cancer theragnostic applications

et al. 2023

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Cancer is a disease caused by abnormal cell growth that spreads through other parts of the body and threatens life by destroying healthy tissues. Therefore, numerous techniques have been employed not only to diagnose and monitor the progress of cancer in a precise manner but also to develop appropriate therapeutic agents with enhanced efficacy and safety profiles. In this regard, molecularly imprinted polymers (MIPs), synthetic receptors that recognize targeted molecules with high affinity and selectivity, have been intensively investigated as one of the most attractive biomaterials for theragnostic approaches. This review describes diverse synthesis strategies to provide the rationale behind these synthetic antibodies and provides a selective overview of the recent progress in the in vitro and in vivo targeting of cancer biomarkers for diagnosis and therapeutic applications. Taken together, the topics discussed in this review provide concise guidelines for the development of novel MIP-based systems to diagnose cancer more precisely and promote successful treatment. Graphical Abstract Molecularly imprinted polymers (MIPs), synthetic receptors that recognize targeted molecules with high affinity and selectivity, have been intensively investigated as one of the most attractive biomaterials for cancer theragnostic approaches. This review describes diverse synthesis strategies to provide the rationale behind these synthetic antibodies and provides a selective overview of the recent progress in the in vitro and in vivo targeting of cancer biomarkers for diagnosis and therapeutic applications. The topics discussed in this review aim to provide concise guidelines for the development of novel MIP-based systems to diagnose cancer more precisely and promote successful treatment.

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“…Disease diagnosis and prediction goals, such as risk assessment, early diagnosis, treatment response prediction, and disease monitoring, are important for the reduction of mortality and the increase of quality of life 86 , 87 . MEVs are novel biomarkers for in vitro diagnostics.…”

Section: Microbial Ev Biogenesismentioning

confidence: 99%

A new horizon of precision medicine: combination of the microbiome and extracellular vesicles

Yang¹,

Shin²,

Kim³

et al. 2022

Exp Mol Med

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Over several decades, the disease pattern of intractable disease has changed from acute infection to chronic disease accompanied by immune and metabolic dysfunction. In addition, scientific evidence has shown that humans are holobionts; of the DNA in humans, 1% is derived from the human genome, and 99% is derived from microbial genomes (the microbiome). Extracellular vesicles (EVs) are lipid bilayer-delimited nanoparticles and key messengers in cell-to-cell communication. Many publications indicate that microbial EVs are both positively and negatively involved in the pathogenesis of various intractable diseases, including inflammatory diseases, metabolic disorders, and cancers. Microbial EVs in feces, blood, and urine show significant differences in their profiles between patients with a particular disease and healthy subjects, demonstrating the potential of microbial EVs as biomarkers for disease diagnosis, especially for assessing disease risk. Furthermore, microbial EV therapy offers a variety of advantages over live biotherapeutics and human cell EV (or exosome) therapy for the treatment of intractable diseases. In summary, microbial EVs are a new tool in medicine, and microbial EV technology might provide us with innovative diagnostic and therapeutic solutions in precision medicine.

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The market trend analysis and prospects of cancer molecular diagnostics kits

Cited by 9 publications

References 0 publications

Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis

Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis

Molecularly imprinted polymers (MIPs): emerging biomaterials for cancer theragnostic applications

A new horizon of precision medicine: combination of the microbiome and extracellular vesicles

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