Located in the Campos Basin, Brazil, the Marlim field, consists of two turbidite systems deposited during eustatic sea-level variations in the Oligocene/Miocene. The reservoir was discovered in 1985, and its production started to decline in 2002. One of the techniques selected to assist in the recovery of oil from the reservoir was the 4D seismic. However, its interpretation can be complex. In order to help address this issue, the present study proposed an analysis of the depletion of a small field area from 1997 to 2010, combining geophysical (4D seismic) and geomechanical (pore pressure) data through the construction of pore pressure 3D models for both years, which can be subtracted and compared to seismic anomalies. The results obtained were: an average depletion of 0.42 ppg (50.33 kg/m3) of pore pressure gradient in the field; the identification of potential fluid-flow barriers, such as an NW-SE-oriented channel and sealing faults; and the detection of two areas with an expressive presence of 4D seismic anomalies, one of them showing a quite evident difference between pore pressure gradients, suggesting field depletion. The use of very old and noisy seismic data hindered the application of this methodology. Nevertheless, this research demonstrated the relevance of estimating pore pressure in the reservoir and how this geomechanical parameter can be useful in assessing the level of field depletion.