The Material Properties of Gelatin Gels

Winter, J.; Shifler, David A.

doi:10.21236/ada008396

Cited by 12 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The density of the gel should vary as ρ gel = b C + √ρ water [28], with the density of water acting as a large offset, modified only weakly by the concentration dependence, which itself is within the square root in Eq 2. Thus the speed of the shear wave should be nearly linearly dependent on gelatine concentration [29].…”

Section: Methodsmentioning

confidence: 99%

Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

et al. 2017

View full text Add to dashboard Cite

Elastography, the imaging of elastic properties of soft tissues, is well developed for macroscopic clinical imaging of soft tissues and can provide useful information about various pathological processes which is complementary to that provided by the original modality. Scaling down of this technique should ply the field of cellular biology with valuable information with regard to elastic properties of cells and their environment. This paper evaluates the potential to develop such a tool by modifying a commercial optical coherence tomography (OCT) device to measure the speed of shear waves propagating in a three-dimensional (3D) medium. A needle, embedded in the gel, was excited to vibrate along its long axis and the displacement as a function of time and distance from the needle associated with the resulting shear waves was detected using four M-mode images acquired simultaneously using a commercial four-channel swept-source OCT system. Shear-wave time of arrival (TOA) was detected by tracking the axial OCT-speckle motion using cross-correlation methods. Shear-wave speed was then calculated from inter-channel differences of TOA for a single burst (the relative TOA method) and compared with the shear-wave speed determined from positional differences of TOA for a single channel over multiple bursts (the absolute TOA method). For homogeneous gels the relative method provided shear-wave speed with acceptable precision and accuracy when judged against the expected linear dependence of shear modulus on gelatine concentration (R2 = 0.95) and ultimate resolution capabilities limited by 184μm inter-channel distance. This overall approach shows promise for its eventual provision as a research tool in cancer cell biology. Further work is required to optimize parameters such as vibration frequency, burst length and amplitude, and to assess the lateral and axial resolutions of this type of device as well as to create 3D elastograms.

show abstract

Section: Methodsmentioning

confidence: 99%

Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Many studies has been conducted about ultrasounds propagation speed in phantom tissues. Based on experiments described in [33], [34] and [35] it has been observed that the ballistic gel sound velocity is slightly lower than in water, exhibiting values around 1450 m s −1 . The ultrasonic pulse propagates inside the gel block in such a way to generate multiple copies as foreseen and discussed above.…”

Section: Measurement Proceduresmentioning

confidence: 99%

Impulse response analysis of an ultrasonic human body channel

Sciacca

Galluccio

2020

Computer Networks

View full text Add to dashboard Cite

Ultrasounds have been successfully and safely employed in underwater communications and for health diagnosis in the last 60 years because of their good performance in environments with high water concentration. Recently it has been proposed also to employ them for supporting intra-body communications; however exploitation of ultrasounds inside the body calls for a deep understanding of their features and a full characterization of the impulse response inside these challenging channels. In this paper we provide a complete experimental characterization of the impulse response inside a human body communication channel, composed for more than 65-70\% of water. To this purpose we developed a testbed which employs a human phantom of ballistic gel to emulate the human body propagation features and performed a set of measurements to fully discuss the channel behavior as a function of different parameters such as the employed frequency, the channel composition and the distance. Our results show that, it is possible to clearly identify the three main components generated by multipath propagation inside the human phantom, i.e. the direct, lateral and reflected waves. Also, it is possible to observe that the excess delay which measures the time elapsed between the first and the last arriving waves, increases approximately as 10 $\mu$s per cm. Our analysis provides interesting has strong implications on the design of communication protocols for intra-body scenarios.

show abstract

“…Silica sphere particle Gelatin sample densities * PC 10 P sample density d = 7.38 μm (±0.08 μm) Gelatin 2.5 wt%: ρ s = 1000 kg/m 3 ρ s = 1020 kg/m 3 ρ p = 1850 kg/m 3 Gelatin 5 wt%: ρ s = 1010 kg/m 3 Gelatin 10 wt%: ρ s = 1030 kg/m 3 * From (Winter, 1975), based on gelatin concentrations.…”

Section: Poncelet Model For Particle Penetrationmentioning

confidence: 99%

High-velocity micro-particle impact on gelatin and synthetic hydrogel

Veysset

Kooi

Maznev

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

The high-velocity impact response of gelatin and synthetic hydrogel samples is investigated using a laser-based microballistic platform for launching and imaging supersonic micro-particles. The micro-particles are monitored during impact and penetration into the gels using a high-speed multi-frame camera that can record up to 16 images with nanosecond time resolution. The trajectories are compared with a Poncelet model for particle penetration, demonstrating good agreement between experiments and the model for impact in gelatin. The model is further validated on a synthetic hydrogel and the applicability of the results is discussed. We find the strength resistance parameter in the Poncelet model to be two orders of magnitude higher than in macroscopic experiments at comparable impact velocities. The results open prospects for testing high-rate behavior of soft materials on the microscale and for guiding the design of drug delivery methods using accelerated microparticles.

show abstract

The Material Properties of Gelatin Gels

Cited by 12 publications

References 2 publications

Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

Impulse response analysis of an ultrasonic human body channel

High-velocity micro-particle impact on gelatin and synthetic hydrogel

Contact Info

Product

Resources

About