The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure

Ruffaner-Hanson, Chaselyn D.; Noor, Shahani; Sun, Melody S.; Solomon, Elizabeth R.; Marquez, Lidia Enriquez; Rodriguez, Dominique E.; Allan, Andrea M.; Bakhireva, Ludmila N.; Milligan, Erin D.

doi:10.1016/j.expneurol.2022.114121

Cited by 27 publications

(18 citation statements)

References 135 publications

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“…In MNR fetuses of both sexes we identified statistically significant increases in cortisol levels. This elevation is likely due to a combination of the fetus receiving less than adequate levels of nutrients for proper growth and reduced handling of maternal cortisol in the insufficient FGR placentas as seen in human cases that leads to increased cortisol crossing the placenta and impacting fetal organ development [64][65][66][67] . Several studies have found increased maternal and fetal cortisol levels during pregnancy lead to increased risk of cognitive delays in the offspring, metabolic diseases, and cardiovascular disorders 60,68,69 .…”

Section: Discussionmentioning

confidence: 99%

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

Davenport,

Wilson,

Williams

et al. 2024

Preprint

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Fetal growth restriction (FGR) caused by placental insufficiency is a major contributor to neonatal morbidity and mortality. There is currently no in utero treatment for placental insufficiency or FGR. The placenta serves as the organ for the developing fetus and offers an excellent opportunity for therapeutic interventions. Here we show efficacy of repeated treatments of trophoblast-specific human insulin-like 1 growth factor (IGF1) gene therapy delivered in a non-viral, polymer nanoparticle to the placenta for the treatment of FGR. Using the guinea pig maternal nutrient restriction model of FGR, nanoparticle-mediated IGF1 treatment was delivered to the placenta via ultrasound guidance across the second half of pregnancy, after establishment of FGR. This treatment resulted in correction of fetal weight in MNR animals compared to control, improved fetal physiology and no negative maternal side-effects. Overall, we show for the first time a therapy capable of improving the entire pregnancy environment: maternal, placental, and fetal. This combined with our previous studies using this therapy at both mid pregnancy and in numerous cell and animal models demonstrate the plausibility of this therapy for future human translation to improve health outcomes of neonates and decrease numerous morbidities associated with the developmental origins of disease.

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Section: Discussionmentioning

confidence: 99%

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

Davenport,

Wilson,

Williams

et al. 2024

Preprint

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show abstract

“…Maternal glucocorticoids can cross the placenta and bind glucocorticoid receptors (GR), which are expressed in the placenta at high levels in decidua, chorion, amnion, and placental villi [ 52 ]. Given that glucocorticoids exert profound effects on fetal development via their beneficial actions on cellular functions and the maturation of fetal organ systems, tight regulation of glucocorticoid action occurs to prevent untimely excess glucocorticoid exposure in utero [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Independent and Combined Effects of Prenatal Alcohol Exposure and Prenatal Stress on Fetal HPA Axis Development

Bakhireva,

Solomon,

Roberts

et al. 2024

IJMS

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Prenatal alcohol exposure (PAE) and prenatal stress (PS) are highly prevalent conditions known to affect fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis. The objectives of this study were to assess the effect of light PAE, PS, and PAE-PS interaction on fetal HPA axis activity assessed via placental and umbilical cord blood biomarkers. Participants of the ENRICH-2 cohort were recruited during the second trimester and classified into the PAE and unexposed control groups. PS was assessed by the Perceived Stress Scale. Placental tissue was collected promptly after delivery; gene and protein analysis for 11β-HSD1, 11β-HSD2, and pCRH were conducted by qPCR and ELISA, respectively. Umbilical cord blood was analyzed for cortisone and cortisol. Pearson correlation and multivariable linear regression examined the association of PAE and PS with HPA axis biomarkers. Mean alcohol consumption in the PAE group was ~2 drinks/week. Higher PS was observed in the PAE group (p < 0.01). In multivariable modeling, PS was associated with pCRH gene expression (β = 0.006, p < 0.01), while PAE was associated with 11β-HSD2 protein expression (β = 0.56, p < 0.01). A significant alcohol-by-stress interaction was observed with respect to 11β-HSD2 protein expression (p < 0.01). Results indicate that PAE and PS may independently and in combination affect fetal programming of the HPA axis.

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“…Hui Li et al (2020), afirmam que entre os marcos anatomofisiológicos da gestação está a formação da placenta, que é um órgão complexo e heterogêneo exclusivo desse período, com potentes mecanismos de proteção, controle das adaptações e regulação da exposição do feto aos agentes influentes e não influentes do processo fisiológico da gravidez, bem como o desenvolvimento fetal adequado. A placenta estabelece um canal único de conexão direta entre o feto e a mãe que medeia a nutrição e oxigenação fetal, nela acontece a síntese de hormônios importantes para o sucesso gestacional e funciona como barreira protetora para o feto (HANSON et al, 2022).…”

Section: Fatores Hormonaisunclassified

Fisioterapia: uma abordagem contemporânea - Volume 4

Silva¹,

Araruna²,

Macedo³

et al. 2023

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A fisioterapia enquanto ciência do movimento humano, estuda os diversos sistemas responsáveis pelo adequado funcionamento das respostas motoras frente aos estímulos recebidos. Nessa obra, encontram-se reunidos trabalhos de conclusão de curso – TCC, abordando de forma integral os temas mais relevantes da área da fisioterapia, servindo de referência bibliográfica para atualização profissional e acadêmica. Os estudos aqui apresentados abrangem temas clássicos, contudo com uma perspectiva da reabilitação atual. Além disso, também estão disponíveis pesquisas que abordam assuntos mais complexos, de forma clara e concisa.

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The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure

Cited by 27 publications

References 135 publications

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

Independent and Combined Effects of Prenatal Alcohol Exposure and Prenatal Stress on Fetal HPA Axis Development

Fisioterapia: uma abordagem contemporânea - Volume 4

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