In the present work, the three dimensional (3D) hydroelasticity characteristics of imperfect lattice sandwich panel (ILSP) subjected to water entry via analytical prediction and numerical simulations are proposed. Firstly, numerical investigations are performed on water entry characteristics based on Arbitrary Eulerian-Lagrange (ALE) coupling method for modeling fluid-structure interaction (FSI) at an impact velocity of 5.0m/s. The results show the impact pressure on total FSI surface of ILSP is generally lower than that of the perfect lattice sandwich panel. Then a novel semi-analytical method to calculate the elastic constants of ILSP is introduced. Based on this approach, an engineering computational model is developed to predict the deformation of ILSP, in which the total deformation is separated into two parts; local field deformation and global field deformation. Good agreement between the numerical and analytical results is achieved. And the effects of geometric parameters such as the thickness of face sheet, height of ILSP and relative density of core are discussed.