We propose a generalized Mathieu's equation (GME) which well describes the dynamics for two different models in spin-1 Bose-Einstein condensates. The stability chart of this GME differs significantly from that of Mathieu's equation and the unstable dynamics under this GME is called generalized parametric resonance. A typical region of ǫ 1 and δ ≈ 0.25 can be used to distinguish these two equations. The GME we propose not only explains the experimental results of Chapman's group [Nat.Commun.7,11233(2016)] in nematic space with a small driving strength, but predicts the behavior in the regime of large driving strength. Besides, the model in spin space we propose, whose dynamics also obeys this GME, can be well tuned such that it is easily implemented in experiments.