The Matrisome, Inflammation, and Liver Disease

Dolin, Christine E.; Arteel, Gavin E.

doi:10.1055/s-0039-3402516

Cited by 23 publications

(21 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned, in some areas of research (e.g., subcutaneous wound healing), the global changes to the ECM in response to acute injury are well-understood. 16 In contrast, research on the hepatic ECM in the context of liver disease has been largely 'collagenocentric' and 'fibrosocentric,' or primarily focused on the role of the collagen ECM during fibrogenesis 65,66 (Fig. 1).…”

Section: Disruption Of the Architecture And Composition Of The Liver Ecm In Diseasesmentioning

confidence: 99%

The liver matrisome – looking beyond collagens

Arteel

Naba

2020

JHEP Reports

Self Cite

View full text Add to dashboard Cite

The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional communication with surrounding cells to regulate cell and tissue homeostasis. The classical definition of the ECM has more recently been extended to include non-fibrillar proteins that either interact or are structurally affiliated with the ECM, termed the 'matrisome.' In addition to providing the structure and architectural support for cells and tissue, the matrisome serves as a reservoir for growth factors and cytokines, as well as a signaling hub via which cells can communicate with their environment and vice-versa. The matrisome is a master regulator of tissue homeostasis and organ function, which can dynamically and appropriately respond to any stress or injury. Failure to properly regulate these responses can lead to changes in the matrisome that are maladaptive. Hepatic fibrosis is a canonical example of ECM dyshomeostasis, leading to accumulation of predominantly collagenous ECM; indeed, hepatic fibrosis is considered almost synonymous with collagen accumulation. However, the qualitative and quantitative alterations of the hepatic matrisome during fibrosis are much more diverse than simple accumulation of collagens and occur long before fibrosis is histologically detected. A deeper understanding of the hepatic matrisome and its response to injury could yield new mechanistic insights into disease progression and regression, as well as potentially identify new biomarkers for both. In this review, we discuss the role of the ECM in liver diseases and look at new "omic" approaches to study this compartment.

show abstract

Section: Disruption Of the Architecture And Composition Of The Liver Ecm In Diseasesmentioning

confidence: 99%

The liver matrisome – looking beyond collagens

Arteel

Naba

2020

JHEP Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…Even in cases where there is a net increase in ECM in liver (e. g. fibrosis), overall turnover is also increased [19]. Importantly, we and others have demonstrated that even acute alcohol-mediated experimental liver injury causes a robust change to the hepatic ECM [11,20].…”

Section: The Ecm Dynamic Remodeling and Disease Progressionmentioning

confidence: 49%

“…This definition has more recently been expanded to also include ECMaffiliated proteins (e. g., collagen-related proteins, transmembrane proteoglycans), ECM regulators and modifiers (e. g., lysyl oxidases, transglutaminases or matrix metalloproteinases) and secreted factors that bind to the ECM (e. g., Transforming growth factor β (TGFβ), and other cytokines) [8]; this expanded definition has been renamed the 'matrisome' [9]. The ECM not only provides structure and mechanical support for the cells in a tissue, but also acts as a reservoir for growth factors and cytokines and as a signaling hub through which cells can communicate with their environment and vice versa [7,10,11].…”

Section: The Ecm Dynamic Remodeling and Disease Progressionmentioning

confidence: 99%

Liver specific, systemic and genetic contributors to alcohol-related liver disease progression

et al. 2022

Self Cite

View full text Add to dashboard Cite

Alcohol-related liver disease (ALD) impacts millions of patients worldwide each year and the numbers are increasing. Disease stages range from steatosis via steatohepatitis and fibrosis to cirrhosis, severe alcohol-associated hepatitis and liver cancer. ALD is usually diagnosed at an advanced stage of progression with no effective therapies. A major research goal is to improve diagnosis, prognosis and also treatments for early ALD. This however needs prioritization of this disease for financial investment in basic and clinical research to more deeply investigate mechanisms and identify biomarkers and therapeutic targets for early detection and intervention. Topics of interest are communication of the liver with other organs of the body, especially the gut microbiome, the individual genetic constitution, systemic and liver innate inflammation, including bacterial infections, as well as fate and number of hepatic stellate cells and the composition of the extracellular matrix in the liver. Additionally, mechanical forces and damaging stresses towards the sophisticated vessel system of the liver, including the especially equipped sinusoidal endothelium and the biliary tract, work together to mediate hepatocytic import and export of nutritional and toxic substances, adapting to chronic liver disease by morphological and functional changes. All the aforementioned parameters contribute to the outcome of alcohol use disorder and the risk to develop advanced disease stages including cirrhosis, severe alcoholic hepatitis and liver cancer. In the present collection, we summarize current knowledge on these alcohol-related liver disease parameters, excluding the aspect of inflammation, which is presented in the accompanying review article by Lotersztajn and colleagues.

show abstract

“…Professor Gavin E. Arteel of the Department of Medicine and the Pittsburgh Liver Research Center at the University of Pittsburgh School of Medicine opened the first session by talking about the metabolism of the extracellular matrix in prefibrotic liver disease. His talk emphasized that there are many additional critical processes occurring in the extracellular matrix (ECM) of the liver during liver disease aside from collagen-and fibrin-dominated fibrosis 1) . He noted that the definition of "ECM" has recently expanded to include not only the fibrillar proteins themselves, but also many regulatory/ modifier proteins and secreted factors that reside in this matrix, which is designated as the "matrisome."…”

Section: St Sessionmentioning

confidence: 99%