The Matrix Metalloproteases and Endothelin‐1 in Infection‐Associated Preterm Birth

Olgun, Nicole S.; Reznik, Sandra E.

doi:10.1155/2010/657039

Cited by 8 publications

(4 citation statements)

References 70 publications

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“…Pro-inflammatory cytokines interact with each other as well as with PGs in a feed-forward cascade, hence amplifying the inflammatory response ( 6 , 7 ). Furthermore, pro-inflammatory cytokines enhance the expression of matrix metalloproteinase (MMPs), which are zinc-dependent enzymes that catalyze the degradation of collagen constituted-extracellular matrix of the cervix, fetal membrane, placenta, and uterus ( 8 – 11 ). Elevated levels of MMP-9 in the maternal plasma, and MMP-3 and MMP-8 in the amniotic fluid are associated with preterm labor (PTL) and/or microbial invasion of the amniotic cavity ( 11 – 13 ).…”

Section: Mechanism Of Inflammation and Infection-associated Preterm Lmentioning

confidence: 99%

Is There a Role for Probiotics in the Prevention of Preterm Birth?

et al. 2015

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Preterm birth (PTB) continues to be a global health challenge. An over-production of inflammatory cytokines and chemokines, as well as an altered maternal vaginal microbiome has been implicated in the pathogenesis of inflammation/infection-associated PTB. Lactobacillus represents the dominant species in the vagina of most healthy pregnant women. The depletion of Lactobacillus in women with bacterial vaginosis (BV) has been associated with an increased risk of PTB. It remains unknown at what point an aberrant vaginal microbiome composition specifically induces the cascade leading to PTB. The ability of oral or vaginal lactobacilli probiotics to reduce BV occurrence and/or dampen inflammation is being considered as a means to prevent PTB. Certain anti-inflammatory properties of lactobacilli suggest potential mechanisms. To date, clinical studies have not been powered with sufficiently high rates of PTB, but overall, there is merit in examining this promising area of clinical science.

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Section: Mechanism Of Inflammation and Infection-associated Preterm Lmentioning

confidence: 99%

Is There a Role for Probiotics in the Prevention of Preterm Birth?

et al. 2015

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“…Although we have previously reported that preventing the action of ET-1 (17), as well of MMPs (30), controls preterm birth individually, the data presented here are the first to show that ET-1 leads to production of MMPs in stimulated gestational tissue just as it does in injured myocardium and other pathologic settings (31). Although the role of endothelin in cardiovascular and other diseases has been investigated, its function in reproductive disorders is not as well understood.…”

Section: O V E M B E R -D E C E M B E R 2 0 1 0 C O N T R O L O F P Rmentioning

confidence: 51%

Prevention of Inflammation-Associated Preterm Birth by Knockdown of the Endothelin-1-Matrix Metalloproteinase-1 Pathway

Wang

Yen

Chen

et al. 2010

Mol Med

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Premature delivery occurs in 12% of all births, accounts for nearly half of neonatal morbidity and is increasing in frequency. Current therapeutic approaches to preterm delivery are ineffective and present serious risks to both the mother and fetus. Although there are multiple factors that contribute to the etiology of preterm birth, the single most common cause is infection. Recently, using cDNA microarray analysis of human placental tissue, we demonstrated that human placental matrix metalloproteinase-1 (MMP-1) is upregulated during labor. In a separate line of investigation, we have shown that blockade of endothelin-1 (ET-1) action through the use of an endothelin-converting enzyme-1 (ECE-1) inhibitor, an established commercially available endothelin receptor antagonist or a novel quinolone-derived endothelin receptor antagonist synthesized by our group also prevents preterm labor and delivery in a mouse model. We have now shown that induction of preterm labor with lipopolysaccharide in our mouse model is associated with increased levels of MMP-1. Furthermore, we showed that silencing the ECE-1/ET-1 pathway by using ECE-1 RNA interference prevents both the onset of preterm labor and upregulation of MMP-1. The data indicate that ET-1 and MMP-1 act in the same molecular pathway in preterm labor.

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“…Histopathological studies demonstrate that PROM is frequently preceded by infection and inflammation of the intra-amniotic cavity and the fetal membranes. Moreover, these inflammatory changes are usually observed near the reported site of membrane rupture (Olgun and Reznik, 2010). In this study, we tried to find the relation between MMP-9 level in maternal serum and its expression in the fetomaternal membranes in cases of PROM at term and determine the histopathological changes of membranes with or without histological chorioamnionitis.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinse-9 expression in fetal membranes and maternal serum in cases of premature rupture of membranes: Impact of subclinical chorioamnionitis

Harras

Mohamed

Lotfy

et al. 2021

International Journal of Cancer and Biomedical Research

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Background: Matrix metalloproteinase-9 (MMP-9) is the most active MMPs in the fetomaternal membranes. It plays an important role in the breakdown and remodeling of these membranes. Thus, increased knowledge of its expression in cases of premature rupture of membranes (PROM) with and without chorioamnionitis (CA) is essential for developing effective treatment strategies. Patients and Methods: expression of MMP-9 in fetomaternal membranes and maternal serum were performed in 70 full-term pregnant women; 20 cases were with intact membranes (group I), 35 with PROM (group IIA) and 15 with PROM and CA (group IIB). Results: A significant difference in MMMP-9 expression was detected between the studied groups. The highest MMP-9 expression was reached in women with PROM accompanied by histological (subclinical) CA followed by women with PROM without CA, compared to the control group (with intact membranes) at the time of delivery. Immunohistochemical expression was associated with a concomitant increase in serum MMP-9. Conclusion: MMP-9 could predict women liable for premature rupture of membranes, and the determination of its serum level may be an effective tool for PROM detection.

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The Matrix Metalloproteases and Endothelin‐1 in Infection‐Associated Preterm Birth

Cited by 8 publications

References 70 publications

Is There a Role for Probiotics in the Prevention of Preterm Birth?

Is There a Role for Probiotics in the Prevention of Preterm Birth?

Prevention of Inflammation-Associated Preterm Birth by Knockdown of the Endothelin-1-Matrix Metalloproteinase-1 Pathway

Matrix metalloproteinse-9 expression in fetal membranes and maternal serum in cases of premature rupture of membranes: Impact of subclinical chorioamnionitis

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