The decline of the feudal system and the progressive rise of the medieval bourgeoisie to power roles and government functions, leads the West (17 th century) to theorize and assume a materialistic, reductionist and mechanistic model of thought, based on a privileged, tendentially exclusive, relationship with Science (Galilean scientific method), technique and technology. This paper takes into account the historical, sociological, and anthropological elements (such as the unlimited perfectibility of humanity advocated by the French Enlightenment and the mechanization of the production cycle envisaged by English proto-liberalism) of this paradigmatic revolution, which more than others help us understanding the causal process that led to contemporary techno-centrism 4.0. It is highlighted that thanks to the interweaving between the ideals of the French Enlightenment, with its two souls (Naturophilus and Technophilus), and the Anglo-Saxon entrepreneurial foresight (proved successful with the Industrial Revolution 1.0), takes shape the Positivist paradigm, and with it the Positivist secular religion, whose affirmation and diffusion generate a stream of widely shared thought throughout the West, i.e. Eugenics, which radicalizes the most ambivalent (pseudo-scientific) and reactionary (philocolonialist) instances of Enlightenment and Positivism, leading to a series of crimes against the person and against humanity, which will result in the mass eliminations conducted, in particular but not only, by Nazi-fascism and Stalinism (two totalitarian regimes that share the same Positivist roots and the same passion for Eugenics thought). It is highlighted that the heart of the industrialization process begins to throb in factories, where the introduction of mechanical systems into the production cycle triggers the man-machine integration process, which soon becomes the fulcrum, the economic, social and cultural driving factor of the western civilization. It will be thanks to the evolution of the mechanical systems employed in the production chains and to the establishment of the Liberalist economic model, that between the second and third Industrial