It is commonly assumed that the properties and geometry of the accretion flow in transient low-mass X-ray binaries (LMXBs) significantly change when the X-ray luminosity decays below ∼ 10 −2 of the Eddington limit (L Edd ). However, there are few observational cases where the evolution of the accretion flow is tracked in a single X-ray binary over a wide dynamic range. In this work, we use NuSTAR and NICER observations obtained during the 2018 accretion outburst of the neutron star LMXB 4U 1608−52, to study changes in the reflection spectrum. We find that the broad Fe-Kα line and Compton hump, clearly seen during the peak of the outburst when the X-ray luminosity is ∼ 10 37 erg s −1 (∼ 0.05 L Edd ), disappear during the decay of the outburst when the source luminosity drops to ∼ 4.5 × 10 35 erg s −1 (∼ 0.002 L Edd ). We show that this non-detection of the reflection features cannot be explained by the lower signal-to-noise at lower flux, but is instead caused by physical changes in the accretion flow. Simulating synthetic NuSTAR observations on a grid of inner disk radius, disk ionisation, and reflection fraction, we find that the disappearance of the reflection features can be explained by either increased disk ionisation (log ξ 4.1) or a much decreased reflection fraction. A changing disk truncation alone, however, cannot account for the lack of reprocessed Fe-Kα emission. The required increase in ionisation parameter could occur if the inner accretion flow evaporates from a thin disk into a geometrically thicker flow, such as the commonly assumed formation of an radiatively inefficient accretion flow at lower mass accretion rates.