The Mayo Clinic Experience With Psychogenic Purpura (Gardner-Diamond Syndrome)

Recurrent painful ecchymosis in an adolescent female

“…Answers: PP – Correct. PP, also known as Gardner-Diamond syndrome or autoerythrocyte sensitization , is a rare syndrome of recurrent painful spontaneous ecchymosis that can be associated with a prodromal phase of itch, pain, and warmth at the site of ecchymosis 1 Urticarial vasculitis – Incorrect.…”

“…A triggering event can often be identified in patients with PP. Postsurgical procedure is the most common, possibly because of the traumatic and emotional stress of recovering from surgery 1 PP is a skin manifestation of an underlying coagulation disorder – Incorrect.…”

“…Psychiatric disease is not a common comorbidity present in patients with PP – Incorrect. Approximately 50% of patients with PP may have an underlying psychiatric disorder, most commonly depression and personality disorder 1 Systemic symptoms are not associated with skin lesions in PP – Incorrect.…”

“…Appearance of new skin lesions in PP may be accompanied by systemic symptoms such as fever, arthralgia, and myalgia. Additionally, gastrointestinal hemorrhages and epistaxis have been reported 1 , 4 Lesions of PP resolve with low rates of recurrence – Incorrect.…”

“…They become less painful and change colors from blue to green and then to yellow before resolving. Unfortunately, lesions do typically recur either in the same location or other parts of the body 1 , 4 …”