Background Tooth loss is an important measure of a population's health condition and has a significant impact on people's quality of life. Oral rehabilitation is an important means for functional and social recovery of edentulous patThe aim of the study was to estimate the budget impact of complete implant-supported dental prostheses in the rehabilitation of mandibular edentulism in patients within the context of the Unified Health System (Sistema Único de Saúde – SUS).Methods Treatment with complete implant-supported dentures was compared with the technology most frequently used - Conventional Complete Dental Prosthesis. For analysis we adopted the Methodology proposed by the Methodological Guidelines for Budget Impact Analysis of the Brazilian Network for Health Technology Assessment (REBRATS). Sensitivity analysis was performed per scenarios and a temporal horizon of 5 years was used.Results Implementation of treatment by complete implant-supported dental prostheses would demand an amount of US$ 970,253,019.00 in 5 years in the reference scenario, US$ 545,767,323.40 in the most optimistic scenario, and US$ 1,516,020,342.40 in the worst scenario.Conclusions These results could support the Brazilian managers in planning the Federal budget destined to Medium to High Complexity (treatments), making it possible to disseminate rehabilitative treatment performed with complete implant-supported dentures in SUS, and serve as reference for health systems in other countries.