The MCP-1, CCL-5 and SDF-1 chemokines as pro-inflammatory markers in generalized anxiety disorder and personality disorders

Ogłodek, Ewa; Szota, Anna; Just, M; Moś, Danuta; Araszkiewicz, Aleksander

doi:10.1016/j.pharep.2014.08.006

Cited by 42 publications

(25 citation statements)

References 30 publications

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“…Furthermore, reduction of the negative symptoms of schizophrenia is combined with the serotonergic system, particularly with antagonism of the 5-HT 2A and/or 5-HT 1A receptors. 38 , 39 By blocking these receptors located on dopaminergic neurons, dopaminergic transmission in the mesocortical pathway is intensified, and as a result, cognitive (such as focusing attention and working memory) and executive functions are improved. On the other hand, an increase in transmission in the nigrostriatal pathway reduces the risk of neuroleptic malignant syndrome through disinhibition.…”

Section: The Influence Of Serotonin and Noradrenaline On Sexual Functmentioning

confidence: 99%

The influence of atypical antipsychotic drugs on sexual function

Just¹

2015

NDT

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Human sexuality is contingent upon many biological and psychological factors. Such factors include sexual drive (libido), physiological arousal (lubrication/erection), orgasm, and ejaculation, as well as maintaining normal menstrual cycle. The assessment of sexual dysfunction can be difficult due to the intimate nature of the problem and patients’ unwillingness to discuss it. Also, the problem of dysfunction is often overlooked by doctors. Atypical antipsychotic treatment is a key component of mental disorders’ treatment algorithms recommended by the National Institute of Health and Clinical Excellence, the American Psychiatric Association, and the British Society for Psychopharmacology. The relationship between atypical antipsychotic drugs and sexual dysfunction is mediated in part by antipsychotic blockade of pituitary dopamine D2 receptors increasing prolactin secretion, although direct correlations have not been established between raised prolactin levels and clinical symptoms. Variety of mechanisms are likely to contribute to antipsychotic-related sexual dysfunction, including hyperprolactinemia, sedation, and antagonism of a number of neurotransmitter receptors (α-adrenergic, dopaminergic, histaminic, and muscarinic). Maintaining normal sexual function in people treated for mental disorders can affect their quality of life, mood, self-esteem, attitude toward taking medication, and compliance during therapy.

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Section: The Influence Of Serotonin and Noradrenaline On Sexual Functmentioning

confidence: 99%

The influence of atypical antipsychotic drugs on sexual function

Just¹

2015

NDT

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“…13 Briefly, blood spots were extracted overnight (18)(19)(20) We assayed 24 immune markers with possible neuro-modulatory roles. [14][15][16][17] Markers included basic fibroblast growth factor, IL-8, IL-1 receptor antagonist (IL-1ra), IL-1 alpha (IL-1α), MCP-1, macrophage inflammatory protein-1 alpha (MIP-1α), MIP-1β, vascular endothelial growth factor (VEGF), 6Ckine, cutaneous T-cell-attracting chemokine (CTACK), IL-16, IL-20, MCP-2, MIP-1d, stromal cell derived factor-1 (SDF-1), thymus and activation regulated chemokine (TARC), soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1 (sVCAM-1), cathepsin D, myeloperoxidase, PDGF-AA, plasminogen activator inhibitor type-1 (PAI-1), neural cell adhesion molecule, and C reactive protein (CRP). Assays of IL-6, IL-5, IL-33, and TNFα resulted in zero values for more than 50% of the population and, therefore, were not further considered in the analysis.…”

Section: Introductionmentioning

confidence: 99%

Concentrations of immune marker in newborn dried blood spots and early childhood development: Results from the Upstate KIDS Study

Ghassabian

Sundaram

Chahal

et al. 2018

Paediatric Perinatal Epid

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“…Additionally, alterations in circulating chemokines {e.g., chemokine C–C motif ligand 2 [CCL2, also referred to monocyte chemoattractant protein-1 (MCP-1)], chemokine C–C motif ligand 11 [CCL11, eotaxin-1], chemokine C–X–C motif ligand 8 [CXCL8, interleukin-8 (IL-8)], and chemokine C–X–C motif ligand 12 [CXCL12, stromal cell-derived factor-1 (SDF-1)]} have been recently associated with psychiatric disorders such as cocaine use disorders (6), mood disorders (7, 8), generalized anxiety (9), personality disorders (9), and Alzheimer’s disease (10). Collectively, these findings suggest that these inflammatory signals could be considered as pathologically relevant biomarkers or therapeutic targets for psychopathologies (11).…”

Section: Introductionmentioning

confidence: 99%

Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity

et al. 2017

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Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To this end, 85 abstinent subjects with AUD from an outpatient setting and 55 healthy subjects were evaluated for substance and mental disorders. Plasma samples were obtained to quantify chemokine concentrations [C–C motif (CC), C–X–C motif (CXC), and C–X3–C motif (CX3C) chemokines]. Abstinent AUD patients displayed a high prevalence of comorbid mental disorders (72%) and other substance use disorders (45%). Plasma concentrations of chemokines CXCL12/stromal cell-derived factor-1 (p < 0.001) and CX3CL1/fractalkine (p < 0.05) were lower in AUD patients compared to controls, whereas CCL11/eotaxin-1 concentrations were strongly decreased in female AUD patients (p < 0.001). In the alcohol group, CXCL8 concentrations were increased in patients with liver and pancreas diseases and there was a significant correlation to aspartate transaminase (r = +0.456, p < 0.001) and gamma-glutamyltransferase (r = +0.647, p < 0.001). Focusing on comorbid psychiatric disorders, we distinguish between patients with additional mental disorders (N = 61) and other substance use disorders (N = 38). Only CCL11 concentrations were found to be altered in AUD patients diagnosed with mental disorders (p < 0.01) with a strong main effect of sex. Thus, patients with mood disorders (N = 42) and/or anxiety (N = 16) had lower CCL11 concentrations than non-comorbid patients being more evident in women. The alcohol-induced alterations in circulating chemokines were also explored in preclinical models of alcohol use with male Wistar rats. Rats exposed to repeated ethanol (3 g/kg, gavage) had lower CXCL12 (p < 0.01) concentrations and higher CCL11 concentrations (p < 0.001) relative to vehicle-treated rats. Additionally, the increased CCL11 concentrations in rats exposed to ethanol were enhanced by the prior exposure to restraint stress (p < 0.01). Concordantly, acute ethanol exposure induced changes in CXCL12, CX3CL1, and CCL11 in the same direction to repeated exposure. These results clearly indicate a contribution of specific chemokines to the phenotype of AUD and a strong effect of sex, revealing a link of CCL11 to alcohol and anxiety/stress.

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The MCP-1, CCL-5 and SDF-1 chemokines as pro-inflammatory markers in generalized anxiety disorder and personality disorders

Abstract: Our study has shown the need for determination of proinflammatory interleukins which are considered as biomarkers of personality disorders and generalized anxiety disorders.

Cited by 42 publications

References 30 publications

The influence of atypical antipsychotic drugs on sexual function

The influence of atypical antipsychotic drugs on sexual function

Concentrations of immune marker in newborn dried blood spots and early childhood development: Results from the Upstate KIDS Study

Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity

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