The mean apparent diffusion coefficient value (ADCmean) on primary cervical cancer is a predictive marker for disease recurrence

Nakamura, Keiichiro; Joja, Ikuo; Nagasaka, Takeshi; Fukushima, Chiharu; Kusumoto, Tetsuya; Seki, Nobuhiko; Hongo, Atsushi; Kodama, Junichi; Hiramatsu, Yuji

doi:10.1016/j.ygyno.2012.07.123

Cited by 78 publications

(73 citation statements)

References 25 publications

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“…The correlation with FIGO stage and lymph node status was also seen by Nakamura et al [33], who additionally showed a significant correlation with lymphovascular space involvement, stromal and parametrial invasion. Other ADC measures showed less or no correlation with any prognostic factors [34][33] [35].…”

Section: Cervical Cancersupporting

confidence: 68%

“…The mean ADC was significant lower in patients with local tumour recurrence or metastasis in the study by Kuang et al [31] and was significantly associated with disease-free survival (DFS) and overall survival (OS) in the study by Micco et al [32]. Multivariate analysis performed by Nakamura et al [33] showed that mean ADC was an independent prognostic factor for DFS after radical hysterectomy. In addition a retrospective study also showed that pre-treatment mean ADC was a prognostic factor for DFS after chemoradiotherapy in univariate analysis, with a trend towards being an independent prognostic factor for recurrence in multivariate analysis (P = 0.066) [36].…”

Section: Cervical Cancermentioning

confidence: 94%

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A literature review of the association between diffusion-weighted MRI derived apparent diffusion coefficient and tumour aggressiveness in pelvic cancer

Bollineni

Krämer

Liu

et al. 2015

Cancer Treatment Reviews

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Section: Cervical Cancersupporting

confidence: 68%

Section: Cervical Cancermentioning

confidence: 94%

A literature review of the association between diffusion-weighted MRI derived apparent diffusion coefficient and tumour aggressiveness in pelvic cancer

Bollineni

Krämer

Liu

et al. 2015

Cancer Treatment Reviews

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“…Nakamura et al [12] indicated that mean ADC of the [3] showed that median ADC of cervical cancer was significantly lower in FIGO stages T1B/T2a compared to T2b and T3/T4. Payne et al showed that there was no significant difference in tumor ADCs when separated by other characteristics like tumor type and lymph node metastases.…”

Section: Discussionmentioning

confidence: 99%

Role of Diffusion-weighted Magnetic Resonance Imaging in Cervical Cancer for Prediction and Monitoring of Chemo-radiotherapy Response

Kala¹,

Bhargavi²,

Avantsa³

et al. 2017

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Objectives: To investigate the possibility of DWI as an imaging bio marker and evaluate its role in prediction and monitoring of chemoradiotherapy response in cervical carcinoma. Methods: 30 carcinoma cervix patients undergoing radiation for Carcinoma Cervix were examined with routine pelvic MRI and DWI before chemoradiation, following EBRT and on completion of brachytherapy. Based on the response on conventional MRI patients were categorized into complete, good and partial response groups. Analysis of variance (ANOVA) and Student t test (two tailed, independent) were used to compare the ADC, size and volume parameters between response groups and therapeutic times. Patients with greater post EBRT tumor ADC changes and greater size and volume responses responded better to therapy. The pretreatment tumor ADC values, post EBRT ADC changes were found to be correlating well with the final outcome. However ADC mapping was less useful in predicting the extension and staging of carcinoma. Conclusion: DWI and its quantitative parameter, ADC has a potential role in the prediction, assessment and monitoring of cervical cancer treatment response to chemo radiation therapy.

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“…Also, they reported that there was an increase in ADC values after radiotherapy, which indicated that DWI might be used to monitor the response to therapy. Moreover in patients with cervical cancer, the measurement of ADC values could be an important factor for assessing response to chemoradiotherapy (23,24). Within the pelvis, cervical cancer spreads first to the parametrial nodes, then to the obturator and iliac nodes.…”

Section: Discussionmentioning

confidence: 99%

Apparent diffusion coefficient value in evaluating types, stages and histologic grading of cancer cervix

Hasan

Enaba

El-Rahman

et al. 2015

The Egyptian Journal of Radiology and Nuclear Medicine

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Aim: To determine whether the apparent diffusion coefficient (ADC) measurements calculated values were significantly different between cervical tumors with different histological characteristics (type, degree of differentiation, and stage of malignancy). Patients and methods: MRI and DWI scans performed in 26 pathologically proved cancer cervix patients. ADC values of different pathological types of cervical cancer were compared. Student's t test was used for statistical analysis. Results: There were 18 squamous cell carcinoma and 8 adenocarcinomas showed with biopsy results. Early stage (FIGO-Ib-IIa, n = 7), (FIGO-IIb-IIIb-IVa, n = 19). The mean ADC values for squamous cell carcinoma (n = 18), and adenocarcinoma (n = 8) were 0.88 · 10 À3 , and 0.91 · 10 À3 mm 2 /s, respectively. Statistical analysis showed significant difference in ADC value between both tumor types (P < 0.05). There was also significant difference between the mean ADC values of the tumor grade I and the other grades (II, III) (p < 0.05). The mean ADC values in early stage cervical cancer (0.83 ± 0.05 · 10 À3 mm 2 /s) were significantly lower than the mean ADC values in late stage disease (0.98 ± 0.06 · 10 À3 mm 2 /s) (p < 0.05). Conclusion: ADC value measurements can provide useful information in diagnosis of cervical cancer as well as in preoperative assessment of the tumor stage.

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The mean apparent diffusion coefficient value (ADCmean) on primary cervical cancer is a predictive marker for disease recurrence

Cited by 78 publications

References 25 publications

A literature review of the association between diffusion-weighted MRI derived apparent diffusion coefficient and tumour aggressiveness in pelvic cancer

A literature review of the association between diffusion-weighted MRI derived apparent diffusion coefficient and tumour aggressiveness in pelvic cancer

Role of Diffusion-weighted Magnetic Resonance Imaging in Cervical Cancer for Prediction and Monitoring of Chemo-radiotherapy Response

Apparent diffusion coefficient value in evaluating types, stages and histologic grading of cancer cervix

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