Fishing activities can alter the structure of marine food webs by the selective removal of some species. The changes in the marine food webs of the Hormuzgan waters of the Persian Gulf, Iran were assessed, based on estimates of the mean trophic index (MTI) and Fishing in Balance index (FiB), and on landing profi le of the exploited marine community (49 species) during the period, 2002-2011. The total landings ( Y t ) ( R =0.88, P <0.001) increased gradually while the Y t of carnivores has slightly declined, and the Y t of herbivores, detritivores and omnivores has increased. Consequently, the MTI signifi cantly decreased ( R =-0.69, P <0.05) at a rate of 0.11 during this decade. The MTI showed a decreasing trend, which indicates exploitation of marine resources. The FiB index also showed a downward trend and negative values from 2002 to 2009, which may be associated with unbalanced structure in the fi sheries, but an upward trend from 2009 to 2011. The time variation of the landing profi le showed two periods with signifi cant diff erences in their species composition ( R =0.88; P =0.005), and based on analysis of similarity, species have been identifi ed as discriminator species, namely Thunnus albacores and Benthosema pterotum . Results indicate that changes in MTI refl ected changes in the Hormuzgan landing structure. The examination of the MTI, FBI, and landing profi le (LP) temporal pattern suggests that the status of fi shery resources in Hormuzgan inshore waters is overexploited, and provides evidence of the probability that a fi shing down process is occurring in this area, and that this trend may continue in the long-term. Therefore, environmental fi sheries management and conservation programs should be prioritized for these valuable resources.