The Measurement of Aggression in the Laboratory

Benton, David

doi:10.1007/978-94-009-8609-1_33

Cited by 8 publications

(1 citation statement)

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“…The behavioural interactions between animal pairs were observed for 10 min and the following behaviours noted: normal social investigation and self-grooming, tail-rattling and direct offensive behaviour, characterized by biting or kicking often accompanied by vocalization (see Benton et al 1984). This behaviour was evaluated using the following individual measures described in detail by Benton (1981): latency(s) to onset of initial offensive encounter, percentage of animals displaying offensive behaviour and the total incidence of offensive encounters per animal. There was a negligible incidence of initiated attacks by standard partners and this was a consequence of the induced anosmia (Benton et al 1984).…”

Section: Methodsmentioning

confidence: 99%

Comparison of the inhibitory action of aminobeclamide and beclamide on socially offensive behaviour

Darmani¹,

Sewell²,

Hasan³

et al. 1990

Journal of Pharmacy and Pharmacology

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The inhibitory effects of aminobeclamide (N-(p-aminobenzyl)-beta-chloropropionamide) on socially offensive behaviour has been studied and compared with those of the parent drug beclamide (N-benzyl-beta-chloropropionamide). Following oral administration in mice which had been individually housed for a 28 day period then paired with normal group-housed opponents, aminobeclamide and beclamide both produced significant and dose-related inhibition of socially offensive behaviour. Aminobeclamide (20-150 mg kg-1 p.o.) and beclamide (50-250 mg kg-1 p.o.) gave increased offense onset latency whilst at the same time they reduced the incidence of offense encounters/animal and decreased the group percentage of animals displaying offense behaviour. It is likely that both drugs have similar monoamine modifying effects though this animal study suggests that aminobeclamide is 1.5 to 2.7 times more potent than beclamide against socially offensive behaviour.

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Section: Methodsmentioning

confidence: 99%