The Measurement of Analgesic Properties of Inhalation Drugs Given in Sub‐anaesthetic Concentrations

Neal, M. J.; Robson, J. M.

doi:10.1111/j.1476-5381.1964.tb01713.x

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…The method and apparatus used in testing for analgesia have been described previously (Neal & Robson, 1964). Unless otherwise stated, the anaesthetic drug was administered with oxygen as the only other gas, and given concentrations are v/v.…”

Section: Methodsmentioning

confidence: 99%

“…An advantage of this method is that it eliminates the subjective element always present in experiments in man, the positive response of the mouse to an electrical shock being an unequivocal squeak. METHODS The method and apparatus used in testing for analgesia have been described previously (Neal & Robson, 1964). Unless otherwise stated, the anaesthetic drug was administered with oxygen as the only other gas, and given concentrations are v/v.…”

mentioning

confidence: 99%

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The Analgesic Properties of Sub‐anaesthetic Doses of Anaesthetics in the Mouse

Neal¹,

Robson²

1964

British Journal of Pharmacology and Chemotherapy

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Trichlorethylene in a sub-anaesthetic concentration (0.5% v/v in oxygen) has an analgesic effect on mice, which develops slowly and reaches a maximum roughly equivalent to that produced by 5 mg/kg of methadone hydrochloride given by intraperitoneal injection. Ethyl chloride causes analgesia in sub-anaesthetic concentrations (3%) but is much less potent than trichlorethylene. Halothane (0.75%) produces slight but definite analgesia. Cyclopropane and diethyl ether have no appreciable analgesic effect. Concentrations of nitrous oxide (up to 90%) in oxygen lack any observable analgesic action on the mouse. Trichlorethylene is considerably potentiated by nitrous oxide, its anaesthetic rather than its analgesic action being affected. Nitrous oxide (40%) potentiates the analgesic rather than the anaesthetic action of halothane (0.75%). However, increasing the concentration of nitrous oxide to 60% causes the anaesthetic action of halothane to predominate.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

The Analgesic Properties of Sub‐anaesthetic Doses of Anaesthetics in the Mouse

Neal¹,

Robson²

1964

British Journal of Pharmacology and Chemotherapy

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“…The analgesic action of the drugs administered in subanaesthetic concentrations was estimated using the method and apparatus described previously (Neal & Robson, 1964a). In outline the method consists of placing two mice at a time in a Perspex gas chamber.…”

Section: Experiments On Micementioning

confidence: 99%

“…The apparatus used to produce known concentrations of anaesthetic has been described (Neal & Robson, 1964a). The anaesthetic vapour in oxygen was led to polyethylene reservoir bags.…”

Section: Experiments On Dogsmentioning

confidence: 99%

The Analgesic and Anaesthetic Actions of Tetrafluorobenzene

Neal

Robson

1966

British Journal of Pharmacology and Chemotherapy

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“…The methods used to assess the significance of the analgesic effect of drugs have been described previously (Neal & Robson, 1964a). To determine whether or not nitrous oxide significantly increased the anaesthetic action of a drug, the probability (P) was calculated as described by Bailey (1959).…”

mentioning

confidence: 99%