The Measurement Precision and Accuracy of T&lt;sub&gt;1&lt;/sub&gt; Mapping Using Polarity Corrected (PC) TI Prep Tool

Ishikawa, Hajime; Seino, Shinya; Takasumi, Hideaki; Kikori, Katsuyuki; Harata, Masahiro; Kanezawa, Takashi; Watanabe, Naoki; Satou, Takanori; Nishina, Takashi; Kuhara, Shigehide

doi:10.6009/jjrt.2018_jsrt_74.1.13

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…This is mainly due to potentially shorter IR pulse intervals and two transient changes in the observed longitudinal relaxation due to shortening and fluctuations in the RR interval. 21,22 We devised an analysis using a recurrence formula to overcome this problem in the PCTIP method and showed that it improved the measurement accuracy, especially at high heart rates. 23 At the same time, that report did not clarify the effect of irregular heart rate variability, and this work examines the effect of this analysis method on this effect.…”

Section: Discussionmentioning

confidence: 99%

“…Phase correction of PCTIP was performed as in PSIR MOLLI, according to a previous report. 21 The polarity of the longitudinal relaxation curve was restored using the real component of the complex signals after correcting for the phase error, whereas T1 analysis was performed from the estimated T1 relaxation curve.…”

Section: Pctip Pulse Sequence and T1 Analysismentioning

confidence: 99%

“…This technique is expected to reduce the underestimation of measured values and the effects of fluctuations owing to heart rate variability caused by multiple readouts in the Look-Locker experiment, which is a concern for the MOLLI. 21,22 However, measurement precision is reportedly reduced, especially for heart-rate variability. This is mainly due to potentially shorter (IR) pulse intervals and transient changes in the observed longitudinal relaxation due to shortening and fluctuations in the RR interval.…”

Section: Introductionmentioning

confidence: 99%

“…This is mainly due to potentially shorter (IR) pulse intervals and transient changes in the observed longitudinal relaxation due to shortening and fluctuations in the RR interval. 21,22 We devised an analysis using a recurrence formula to overcome this problem using the PCTIP method and reported its usefulness for heart rate variability at a constant RR interval. 23 However, in clinical situations, there are concerns about further complex RR fluctuations due to physiological RR interval variations caused by breath-holding and arrhythmias caused by diseases such as extrasystoles.…”

Section: Introductionmentioning

confidence: 99%

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Novel T1 Analysis Method to Address Reduced Measurement Accuracy Due to Irregular Heart Rate Variability in Myocardial T1 Mapping Using Polarity-corrected Inversion Time Preparation

Endo,

Takahashi,

Shibo

et al. 2025

MRMS

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Purpose: Polarity-corrected inversion time preparation (PCTIP), a myocardial T1 mapping technique, is expected to reduce measurement underestimation in the modified Look-Locker inversion recover method. However, measurement precision is reduced, especially for heart rate variability. We devised an analysis using a recurrence formula to overcome this problem and showed that it improved the measurement accuracy, especially at high heart rates. Therefore, this study aimed to determine the effect of this analysis on the accuracy and precision of T1 measurements for irregular heart rate variability.Methods: A PCTIP scan using a 3T MRI scanner was performed in phantom experiment. We generated the simulated R-waves required for electrocardiogram (ECG)-gated acquisition using a signal generator set to 30 combinations. T1 map was generated using the signal train of the PCTIP images by nonlinear curve fitting using conventional and recurrence formulas. Accuracy against reference T1 and precision of heart rate variability were evaluated. To evaluate the fitting accuracy of both analyses, the relative fitting error was calculated.Results: For the longer T1, the fitting error was larger than the short T1, with the conventional analysis showing 10.1 ± 2.0%. The recurrence formula analysis showed a small fitting error less than 1%, which was consistent for all heart rate variability patterns. In the conventional analysis, the accuracy, especially for longer T1, showed a large underestimation of the measurements and poor linearity. However, in the recurrence formula analysis, the accuracy improved at a long T1, and linearity also improved. The Bland-Altman plot showed that it varied greatly depending on the heart rate variability pattern for the longer T1 in the conventional analysis, whereas the recurrence formula analysis suppressed this variation.Conclusion: T1 analysis of PCTIP using the recurrence formula analysis achieved accurate and precise T1 measurements, even for irregular heart rate variability.

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Section: Discussionmentioning

confidence: 99%

Section: Pctip Pulse Sequence and T1 Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel T1 Analysis Method to Address Reduced Measurement Accuracy Due to Irregular Heart Rate Variability in Myocardial T1 Mapping Using Polarity-corrected Inversion Time Preparation

Endo,

Takahashi,

Shibo

et al. 2025

MRMS

Self Cite

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“…We used a novel pulse sequence for T1 mapping and the values cannot be compared directly with other pulse sequences. The intrinsic measurement errors of this pulse sequence compared with conventional inversion-recovery spin-echo for T1 measurements were evaluated in phantom studies and estimated a low mean measurement error of 7.4 ± 3.8 % [48,49].…”

Section: Study Limitationsmentioning

confidence: 99%

Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users

et al. 2021

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Anabolic androgenic steroid (AAS) abuse leads to myocardial toxicity. Human studies are conflicting about the myocardial fibrosis in AAS users. We evaluated cardiac tissue characterization, left ventricle (LV) function, and cardiac structure by cardiovascular magnetic resonance (CMR). Twenty strength-trained AAS users (AASU) aged 29±5 yr, 20 strength-trained AAS nonusers (AASNU), and 7 sedentary controls (SC) were enrolled. Native T1 mapping, late-gadolinium enhancement (LGE), extracellular volume (ECV), and myocardial strain were evaluated. AASU showed lower Native T1 values than AASNU (888±162 vs. 1020±179 ms p=0.047). Focal myocardial fibrosis was found in 2 AASU. AASU showed lower LV radial strain (30±8 vs. 38±6%, p<0.01), LV circumferential strain (–17±3 vs. −20±2%, p<0.01), and LV global longitudinal strain (–17±3 vs. –20±3%, p<0.01) than AASNU by CMR. By echocardiography, AASU demonstrated lower 4-chamber longitudinal strain than AASNU (–15±g3 vs. –18±2%, p=0.03). ECV was similar among AASU, AASNU, and SC (28±10 vs. 28±7 vs. 30±7%, p=0.93). AASU had higher LV mass index than AASNU and SC (85±14 vs. 64±8 vs. 58±5 g/m2, respectively, p<0.01). AAS abuse may be linked to decreased myocardial native T1 values, impaired myocardial contractility, and focal fibrosis. These alterations may be associated with maladaptive cardiac hypertrophy in young AAS users.

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Evaluation of the homogeneity of native T1 myocardial mapping using the polarity corrected inversion time preparation method in a myocardial phantom and healthy volunteers

Takasumi

Seino

Kikori

et al. 2021

Radiol Phys Technol

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The Measurement Precision and Accuracy of T<sub>1</sub> Mapping Using Polarity Corrected (PC) TI Prep Tool

Cited by 4 publications

References 9 publications

Novel T1 Analysis Method to Address Reduced Measurement Accuracy Due to Irregular Heart Rate Variability in Myocardial T1 Mapping Using Polarity-corrected Inversion Time Preparation

Novel T1 Analysis Method to Address Reduced Measurement Accuracy Due to Irregular Heart Rate Variability in Myocardial T1 Mapping Using Polarity-corrected Inversion Time Preparation

Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users

Evaluation of the homogeneity of native T1 myocardial mapping using the polarity corrected inversion time preparation method in a myocardial phantom and healthy volunteers

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