The mechanism and nature of ventricular fibrillation

Wiggers, Carl J.

doi:10.1016/s0002-8703(40)90874-2

Cited by 303 publications

(63 citation statements)

References 12 publications

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“…allometry ͉ spiral waves ͉ ventricular fibrillation V entricular fibrillation (VF) is an extremely abnormal heart rhythm that impedes blood pumping to the brain and vital organs, resulting in sudden death (1). VF has been described as turbulent cardiac electrical activity, and several hypotheses have been put forth to explain the very complex electrical behavior that characterizes it.…”

mentioning

confidence: 99%

Universal scaling law of electrical turbulence in the mammalian heart

Noujaim

Berenfeld

Kalifa

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Many biological processes, such as metabolic rate and life span, scale with body mass (BM) according to the universal law of allometric scaling: Y ‫؍‬ aBM b (Y, biological process; b, scaling exponent). We investigated whether the temporal properties of ventricular fibrillation (VF), the major cause of sudden and unexpected cardiac death, scale with BM. By using high-resolution optical mapping, numerical simulations and metaanalysis of VF data in 11 mammalian species, we demonstrate that the interbeat interval of VF scales as VFcycle length ‫؍‬ 53 ؋ BM 1/4 , spanning more than four orders of magnitude in BM from mouse to horse.allometry ͉ spiral waves ͉ ventricular fibrillation

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mentioning

confidence: 99%

Universal scaling law of electrical turbulence in the mammalian heart

Noujaim

Berenfeld

Kalifa

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…In electrically-induced ventricular fibrillation, Wiggers (1940) found that large areas of myocardium continued to contract in unison for a few seconds after the onset of the condition. The electrocardiogram in this case is characterized by large waves which become progressively smaller.…”

Section: Discussionmentioning

confidence: 99%

Further observations on the experimental antidysrhythmic activity of indoramin hydrochloride

Rashid¹,

Alps²

1973

Journal of Pharmacy and Pharmacology

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Indoramin showed potent activity in reversing severe myocardial conduction disorders and ventricular fibrillation induced by hypothermia, and protected against the precipitation of electrically-induced ventricular fibrillation at low doses in pentobarbitone-anaesthetized cats. It would appear that the a-adrenoceptor blocking and local anaesthetic membrane stabilizing properties of indoramin are responsible for the mechanisms by which these dysrhythmias are reversed as they are with those induced by ouabain and adrenaline, previously described.Indoramin has been shown, in animal experiments, to be a potent hypotensive drug possessing a-adrenoceptor blocking and myocardial inhibitory properties (Alps, Hill & others, 1972; Alps, Borrows, & others, 1972). Whilst indoramin does not depress the myocardium by p-adrenoceptor blockade it does possess local anaesthetic activity, and in an attempt to examine this property further the drug was examined for antidysrhythmic activity against adrenaline and ouabain-induced irregularities. As a result, indoramin was found to possess potent antidysrhythmic properties (Alps, Hill & others, 1971).The antidysrhythmic actions of indoramin have now been further investigated using dysrhythmias induced by hypothermia and electrically-induced ventricular fibrillation (Szekeres & Papp, 1971) in anaesthetized cats. METHODS Dysrhythmias induced by hypothermiaThree cats of either sex, 1.6 to 2.0 kg, were anaesthetized with pentobarbitone-sodium (30 mg kg-l, intrathoracically). The trachea was cannulated and the animals were ventilated artificially by a Palmer respirator. The cephalic vein and carotid artery were prepared for injection of test compounds and for recording left ventricular blood pressure respectively. The left femoral artery was divided and cannulated at two points. The cannala from the upper abdominal end was connected via a WatsonMarlow peristaltic pump, through fine bore tubing to a glass coil connected to the cannula inserted into the peripheral femoral artery. The glass coil was immersed in ice and ice bags were placed around the animals to lower body temperature. The blood was circulated through the cooling system and reintroduced into the peripheral cut end of the femoral artery. Rectal temperature was monitored by means of a glass thermometer.

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“…Intervals between successive action potentials were regular, and the amplitude of the alternating smaller action potentials was constant. At the left hand of strip B, intervals between successive action potentials became irregular, as Fig,3. Three different portions of a long continuous strip.…”

Section: Observations In Isolated Perfused Rabbit Heartsmentioning

confidence: 91%