Flow-induced vibration (FIV) poses risks to engineering systems, prompting efforts for safety. Valves, crucial for fluid control, can induce turbulence-related mechanical loads, leading to vibration and potential failures. This paper combines experimental and numerical methods, using computational fluid dynamics (CFD) for flow analysis. A test loop with nine pressure sensors assesses water flow through a globe valve, testing various conditions. Dimensionless power spectral density (PSD) of pressure fluctuations is compared with CFD results. Steady simulations precede computational fluid dynamics – large eddy simulation (CFD-LES) for quantitative data. Industrial-scale valve analysis explores scalability using different protocols, contributing to design strategy improvements.