The Mechanism of Action of Ethoxidol on Oxidative Stress Indices in Heart Failure and Hypotension

Abstract

The aim of the investigation was to study the effect of 2-ethyl-6-methyl-3-hydroxypyridine malate (Ethoxidol) on the concentration of oxidative stress metabolites in patients with chronic heart failure (CHF) and hypertension. Materials and Methods. 126 patients with FC I-III CHF have been examined. In addition to their individual therapy these patients received intravenous infusions of Ethoxidol. Blood content of 2,3-diphosphoglycerate (2,3-DPG), oxygen tension (рО 2), pH, concentration of total peroxides, lactate, and aldosterone were identified. 2,3-DPG levels (g/L erythrocytes) in whole blood samples were determined by an enzyme assay using the reagent kit (Rosh, Germany), values of рО 2 , рСО 2 , рН, lactate in the venous blood were measured using gas analyzer Stat Profil pHOx Ultra (Nova Biomedical, USA). Indices of oxidative stress, i.e. the concentration of plasma total peroxides, were investigated by ELISA using OxyStat kit (Biomedica, Austria). Peripheral venous blood samples were collected from all patients before and 6 days after the daily intravenous Ethoxidol infusion. Results. In patients with FC I, II, III CHF, on day 7 after intravenous Ethoxidol infusion at a dose of 100 mg/day, statistically significant growth (p=0.0002) of PaO 2 level by 15.7, 17.4, and 22.8%, respectively, was noted. In patients with FC I, II, III CHF in the group receiving standard therapy, statistically significant (p=0.002) reduction of 2,3-DPG level by 2.7, 2.4, and 4.0%, respectively, was registered. On day 7 after the infusion of Ethoxidol at a dose of 100 mg/day, its decrease by 5.7, 10.5, and 26.2%, respectively (p<0.0001), was also observed.

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

“…The use of catalytic antioxidants, such as SOD/catalase mimetics and functional GPx mimetics, was greatly developed in the experiment, but no significant changes were detected in clinical conditions [84]. Among domestic drugs, ethylmethylhydroxypyridine malate and ethylmethylhydroxypyridine succinate exhibiting antioxidant, antihypoxic, and membrane-protective properties against vascular DM complications should be mentioned [9].…”

The role of oxidative stress in the pathogenesis of socially significant human diseases and ways of its drug correction

“…ЭМГПМ также способен повышать активность кальцийнезависимой фосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы (мембраносвязанных ферментов), рецепторов гамма-аминомасляной кислоты (ГАМК), ацетилхолинового комплексов (рецепторных комплексов); это усиливает их способность связывания с лигандами [32,33]. Препарат целесообразно принимать в составе комплексной терапии при лечении ишемической болезни сердца и ишемического инсульта, а также при легких и умеренных когнитивных расстройствах и дисциркуляторной энцефалопатии [34,35].…”

Dynamics of glutathione reductase activity in rat liver tissues during cryodestruction of the right atrium

“…Reactive oxygen species also damage vascular endothelium and reduce nitric oxide (II) secretion, which provokes endothelial dysfunction manifested by increased vasoconstriction, hypercoagulation and proliferation of muscle cells [4]. Reactive oxygen species destroy cell membranes, which leads to the formation of a large number of free radicals, which in turn damage cardiomyocytes, and as a result myocardial contractile function deteriorates [5,6].…”

“…Oxidative stress also reduces the activity of many enzymes and substances, including 2,3-diphosphoglycerate (2,3-DPG), which is localized in erythrocytes and affects their most important function -oxygen transport. A change in the amount of 2,3-DPG changes hemoglobin affinity for oxygen and thus accelerates the dissociation of oxyhemoglobin into hemoglobin and oxygen, while a decrease in 2,3-DPG contributes to a decrease in oxygen tension in the blood [4,9,10 ].…”