The mechanism of apoptosis of Chlamys farreri hemocytes under benzopyrene stress in vitro

Tian, Yimeng; Pan, Luqing; Miao, Jingjing; Lei, Fengjun; Xu, Ruiyi; Zhang, Xin

doi:10.1016/j.scitotenv.2021.148731

Cited by 18 publications

(3 citation statements)

References 76 publications

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“…There is a multitude of factors by which soot microparticles can induce programmed cell death. A pronounced proapoptotic effect is known for soot PAHs: fluorene and phenanthrene [101], benz[a]pyrene [102][103][104][105], dibenzo[a,l]pyrene [106], 7,12-dimethylbenz[a]anthracene [104,107], 1-methylpyrene and perylene [108], fluoranthene [109], and 3-nitrofluoranthene [110]. Other soot components that can cause a cytotoxic effect are the metals associated with soot microparticles (Mn, Al) and silica, which we identified previously [39].…”

Section: Programmed Cell Death In Gill Epithelium Under the Influence...mentioning

confidence: 99%

Degenerative and Regenerative Actin Cytoskeleton Rearrangements, Cell Death, and Paradoxical Proliferation in the Gills of Pearl Gourami (Trichogaster leerii) Exposed to Suspended Soot Microparticles

Sudakov,

Chang,

Renn

et al. 2023

IJMS

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The effect is studied of water-suspended soot microparticles on the actin cytoskeleton, apoptosis, and proliferation in the gill epithelium of pearl gourami. To this end, the fish are kept in aquariums with 0.005 g/L of soot for 5 and 14 days. Laser confocal microscopy is used to find that at the analyzed times of exposure to the pollutant zones appear in the gill epithelium, where the actin framework of adhesion belts dissociates and F-actin either forms clumps or concentrates perinuclearly. It is shown that the exposure to soot microparticles enhances apoptosis. On day 5, suppression of the proliferation of cells occurs, but the proliferation increases to the control values on day 14. Such a paradoxical increase in proliferation may be a compensatory process, maintaining the necessary level of gill function under the exposure to toxic soot. This process may occur until the gills’ recovery reserve is exhausted. In general, soot microparticles cause profound changes in the actin cytoskeleton in gill cells, greatly enhance cell death, and influence cell proliferation as described. Together, these processes may cause gill dysfunction and affect the viability of fish.

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Section: Programmed Cell Death In Gill Epithelium Under the Influence...mentioning

confidence: 99%

Degenerative and Regenerative Actin Cytoskeleton Rearrangements, Cell Death, and Paradoxical Proliferation in the Gills of Pearl Gourami (Trichogaster leerii) Exposed to Suspended Soot Microparticles

Sudakov,

Chang,

Renn

et al. 2023

IJMS

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“…Due to the elimination capacity of CeO 2 PCFs for ROS and B(a)P, it may be feasible to deal with some harmful gases (Scheme B). In addition, the metabolism of B(a)P may produce large amounts of ROS in vivo . Excess ROS produced under stress environments is a challenge for the growth of the plant.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the metabolism of B(a)P may produce large amounts of ROS in vivo. 28 Excess ROS produced under stress environments is a challenge for the growth of the plant. B(a)P can also be inhaled by some crops and influence food safety.…”

Section: Introductionmentioning

confidence: 99%

CeO₂-Based Porous Carbonaceous Frameworks as Antioxidant Nanozymes for Scavenging Reactive Oxygen Species and Adsorbing Benzo[a]pyrene

et al. 2023

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Barbecue smoke, car exhaust, cigarette smoke, and other waste gases contain toxic reactive oxygen species (ROS) and polycyclic aromatic hydrocarbons (PAHs). Herein, CeO 2 -based porous carbonaceous frameworks (CeO 2 PCFs) were explored as antioxidant nanozymes to scavenge ROS and absorb benzo[a]pyrene (B[a]P). Using cerium-based frameworks as the precursors, CeO 2 PCFs were constructed by high-temperature calcination. Due to excellent superoxide dismutase-like and catalase-like activity, CeO 2 PCFs could effectively eliminate superoxide radical, hydroxyl radical, and hydrogen peroxide. The 2,2′-azino-bis (3ethylbenzthiazoline-6-sulfonic acid) free radical scavenging assay had substantiated free radical scavenging ability of CeO 2 PCFs. In addition, with a large surface area and porous structure, CeO 2 PCFs could adsorb B[a]P efficiently. The designed CeO 2 PCFs may provide a new opportunity as scavengers of ROS and absorbents of PAHs in some harmful gases.

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Potential pathway and mechanisms underlining the immunotoxicity of benzo[a]pyrene to Chlamys farreri

Lei

Zhang

Miao

et al. 2023

Environ Sci Pollut Res

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The mechanism of apoptosis of Chlamys farreri hemocytes under benzopyrene stress in vitro

Cited by 18 publications

References 76 publications

Degenerative and Regenerative Actin Cytoskeleton Rearrangements, Cell Death, and Paradoxical Proliferation in the Gills of Pearl Gourami (Trichogaster leerii) Exposed to Suspended Soot Microparticles

Degenerative and Regenerative Actin Cytoskeleton Rearrangements, Cell Death, and Paradoxical Proliferation in the Gills of Pearl Gourami (Trichogaster leerii) Exposed to Suspended Soot Microparticles

CeO₂-Based Porous Carbonaceous Frameworks as Antioxidant Nanozymes for Scavenging Reactive Oxygen Species and Adsorbing Benzo[a]pyrene

Potential pathway and mechanisms underlining the immunotoxicity of benzo[a]pyrene to Chlamys farreri

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The mechanism of apoptosis of Chlamys farreri hemocytes under benzopyrene stress in vitro

Cited by 18 publications

References 76 publications

Degenerative and Regenerative Actin Cytoskeleton Rearrangements, Cell Death, and Paradoxical Proliferation in the Gills of Pearl Gourami (Trichogaster leerii) Exposed to Suspended Soot Microparticles

Degenerative and Regenerative Actin Cytoskeleton Rearrangements, Cell Death, and Paradoxical Proliferation in the Gills of Pearl Gourami (Trichogaster leerii) Exposed to Suspended Soot Microparticles

CeO2-Based Porous Carbonaceous Frameworks as Antioxidant Nanozymes for Scavenging Reactive Oxygen Species and Adsorbing Benzo[a]pyrene

Potential pathway and mechanisms underlining the immunotoxicity of benzo[a]pyrene to Chlamys farreri

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CeO₂-Based Porous Carbonaceous Frameworks as Antioxidant Nanozymes for Scavenging Reactive Oxygen Species and Adsorbing Benzo[a]pyrene