The mechanism of cuproptosis in Parkinson’s disease

Huang, Min; Zhang, Yong; Liu, Xuehong

doi:10.1016/j.arr.2024.102214

Cited by 6 publications

(1 citation statement)

References 87 publications

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“…The effect of copper on depression is controversial. The participation of copper in the conversion of dopamine to norepinephrine suggests a potential role in depression development [ 45 ]. However, excessive copper can cause oxidative damage to cells and tissues due to redox activity [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Wang,

Liu,

Yang

2024

Actas Esp Psiquiatr

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Background: Previous observational studies have discovered a connection between depression and mineral status. Confirming this potential connection is challenging due to confounding factors and potential reverse causality which is inherent in observational studies. Materials and Methods: We performed a Mendelian randomization (MR) analysis to estimate the causal association of serum minerals with depression. Leveraging summary-level data on depression, a genome-wide association study (GWAS) was applied. The data on serum minerals were collected from the FinnGen Biobank database. MR assessments representing causality were produced by inverse-variance weighted approaches with multiplicative random and fixed effects. Result: Sensitivity analyses were performed to validate the reliability of the results. A noteworthy correlation emerged between serum zinc levels and reduced risk of depression. An odds ratio (OR) of 0.917 for depression associated with a one standard deviation increase in serum zinc levels (OR = 0.968; 95% CI = 0.953–0.984, p = 1.19 × 10-4, random effects model inverse variance weighted (IVW)); (OR = 0.928; 95% CI = 0.634–1.358, p = 0.766, MR Egger). Sensitivity assessments supported this causation. However, the risk of depression did not exhibit an association with other minerals. Conclusions: In summary, a higher zinc concentration is causally associated with a reduced depression risk. This MR outcome may assist clinicians in the regulation of specific mineral intake, particularly for high-risk patients with serum zinc deficiencies.

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Section: Discussionmentioning

confidence: 99%

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Wang,

Liu,

Yang

2024

Actas Esp Psiquiatr

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Bhat,

Afzal,

Moglad

et al. 2024

Clin Exp Med

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Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies have demonstrated that copper accumulation induces a unique form of cell death known as cuproptosis, with lncRNAs playing a key role in regulating cuproptosis-associated pathways. These lncRNAs may trigger cell-specific responses to copper stress, presenting new opportunities as prognostic markers and therapeutic targets. This paper delves into the role of lncRNAs in cuproptosis-mediated cancer, underscoring their potential as biomarkers and targets for innovative therapeutic strategies. A thorough review of scientific literature was conducted, utilizing databases such as PubMed, Google Scholar, and ScienceDirect, with search terms like 'lncRNAs,' 'cuproptosis,' and 'cancer.' Studies were selected based on their relevance to lncRNA regulation of cuproptosis pathways and their implications for cancer prognosis and treatment. The review highlights the significant contribution of lncRNAs in regulating cuproptosis-related genes and pathways, impacting copper metabolism, mitochondrial stress responses, and apoptotic signaling. Specific lncRNAs are potential prognostic markers in breast, lung, liver, ovarian, pancreatic, and gastric cancers. The objective of this article is to explore the role of lncRNAs as potential prognostic markers and therapeutic targets in cancers mediated by cuproptosis.

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Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases

Yang,

Feng,

Zhao

2024

Apoptosis

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The mechanism of cuproptosis in Parkinson’s disease

Cited by 6 publications

References 87 publications

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases

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