The mechanism of interaction of carnosine with superoxide radicals in water solutions

Павлов, А. В.; Ревина, А. А.; Дупин, А. М.; Boldyrev, Alexander A.; Yaropolov, A. I.

doi:10.1016/0304-4165(93)90114-n

Cited by 82 publications

(48 citation statements)

References 12 publications

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“…At physiological concentrations in muscle, carnosine can interact with singlet oxygen and scavenge peroxyl radicals [41] and superoxide radicals [42]. Therefore, carnosine can reduce the products of lipid peroxidation (TBARS, malondialdehyde) and act as a natural hydrophylic antioxidant [5;43;44].…”

Section: Anti-oxidative Potential Metal Chelation and Anti-glycationmentioning

confidence: 99%

Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training

et al. 2010

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Section: Anti-oxidative Potential Metal Chelation and Anti-glycationmentioning

confidence: 99%

Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training

et al. 2010

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“…The antioxidant capacity of this compound is well documented, as well as its pH buffering, osmoregulating, and metalchelating abilities (Boldyrev, 1990). A potentially useful characteristic of CARN is its ability to act as an anti-glycating agent (Boldyrev, 2002;Boldyrev, 2005;Hipkiss et al, 1998;Hipkiss & Brownson, 2000), to quench superoxide anion and hydroxide radical (Pavlov, et al 1993;Rubtsov et al, 1991) and to neutralize 4-hydroxy-nonenal (HNE) and other toxic aldehydes (Aldini et al, 2002, Liu et al, 2003. In order to study the efficiency of carnosine as geroprotector, senescence accelerated mice (SAM), which have increased levels of ROS and deficiency of antioxidant capacity, was used (Boldyrev et al, 2001;Yuneva et al, 2002).…”

Section: Endogenous Antioxidantsmentioning

confidence: 99%

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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“…The activity showed by these dipeptides is due to the imidazole moiety of the molecule, and consists of several anti-oxidant properties, i.e. stabilization of membranes (Boldyrev et al, 1988), scavenging of free radical intermediates (Kohen et al, 1988;Salim-Hanna et al, 1991;Pavlov et al, 1993), chelation of divalent transition metals such as iron, copper and zinc (Brown, 1981;Kohen et al, 1988;Klebanov et al, 1998), elimination of lipid peroxidation products in a nonenzymatic way Dupin et al, 1987). These properties are strictly related to each other; for example, important compounds in free radical biochemistry, such as hydrogen peroxide, in the presence of transition metal ions produce the more reactive and damaging hydroxyl radical (Cheeseman and Slater, 1993).…”

Section: Antioxidant Effectmentioning

confidence: 99%

Carnosine-related dipeptides in the mammalian brain

Bonfanti

Peretto

Marchis

et al. 1999

Progress in Neurobiology

190

107

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-Carnosine and structurally related dipeptides are a group of histidine-containing molecules widely distributed in vertebrate organisms and particularly abundant in muscle and nervous tissue. Although many theories have been proposed, the biological function(s) of these compounds in the nervous system remains enigmatic. The purpose of this article is to review the distribution of carnosine-related dipeptides in the mammalian brain, with particular reference to some cell populations wherein these molecules have been demonstrated to occur very recently. The high expression of carnosine in the mammalian olfactory receptor neurons led to infer that this dipeptide could play a role as a neurotransmitter/modulator in olfaction. This prediction, which has not yet been fully demonstrated, does not explain the localization of carnosine-related dipeptides in other cell types, such as glial and ependymal cells. A recent demonstration of high carnosine-like immunoreactivity in the subependymal layer of rodents, an area of the forebrain which shares with the olfactory neuroepithelium the occurrence of continuous neurogenesis during adulthood, supports the hypothesis that carnosine-related dipeptides could be implicated in some forms of structural plasticity. However, the particular distribution of these molecules in the subependymal layer, along with their expression in glial/ependymal cell populations, suggests that they are not directly linked to cell migration or cell renewal. In the absence of a unified theory about the role of carnosine-related dipeptides in the nervous system, some common features shared by different cell populations of the mammalian brain which contain these molecules are discussed.

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The mechanism of interaction of carnosine with superoxide radicals in water solutions

Cited by 82 publications

References 12 publications

Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training

Muscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Carnosine-related dipeptides in the mammalian brain

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