The Mechanism of Mitosis Based on Studies of the Submicroscopic Structure and of the Living State of the &lt;i&gt;Tradescantia&lt;/i&gt; Cell

Wada, Bungo

doi:10.1508/cytologia.16.1

Cited by 64 publications

(49 citation statements)

References 25 publications

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“…The kinetochore fiber shortening theory has been demonstrated not only in fixation cytology but also in experiments on living mitotic cells under in vivo observations (Wada 1935, Wada and Izutsu 1961, Shimamura 1940. Despite of this fact, it becomes the fashion at present to try to interpret the movement of chromosomes in anaphase by means of microtubules, tubulin or ATP all based alone on the concept of the so-called mitotic apparatus.…”

Section: ) Chromosome Movement In Anaphasementioning

confidence: 95%

“…The birefringent figures of mitotic spindles have been revealed to correspond to the optical vacuum area appearing under the dark-field microscope (Fujii 1931). Based on the observations mentioned above, it may be concluded that the atractoplasm is constituted of submicroscopic fibrils which arrange themselves optically anisotropic lying parallel to the spindle axis (Wada 1950(Wada , 1966. In this way Inoue has for the first time shed light on the elucidation of the spindle mechanism at the molecular level.…”

Section: ) Mitotic Spindles In Living Cells Observed Under Dark-fielmentioning

confidence: 99%

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Mitotic cell studies based on in vivo observations. XI. Various causes which prevent an elucidation of mitosis.

Wada¹

1981

CYTOLOGIA

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Section: ) Chromosome Movement In Anaphasementioning

confidence: 95%

Section: ) Mitotic Spindles In Living Cells Observed Under Dark-fielmentioning

confidence: 99%

Mitotic cell studies based on in vivo observations. XI. Various causes which prevent an elucidation of mitosis.

Wada¹

1981

CYTOLOGIA

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“…Bungo Wada working with living Tradescantia stamen hair cells proposed that "the disintegration of each fiber from its distal end to the kinetochore […] takes place in the spindle poles, and the traction fibers are drawn continuosly into the spindle poles […] and bring their kinetochore to the spindle poles" [38]. In Haemanthus endosperm, granules in front of a kinetochore at the start of anaphase move at the same speed of chromosomes in anaphase and the distance between granules and kinetochores does not change for a considerable period, supporting that k-fibers shorten essentially from their pole-associated end [39].…”

Section: Force Generation By Microtubule Depolymerization At Minus-endsmentioning

confidence: 99%

The perpetual movements of anaphase

Maiato

Lince-Faria

2010

Cell. Mol. Life Sci.

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One of the most extraordinary events in the lifetime of a cell is the coordinated separation of sister chromatids during cell division. This is truly the essence of the entire mitotic process and the reason for the most profound morphological changes in cytoskeleton and nuclear organization that a cell may ever experience. It all occurs within a very short time window known as "anaphase", as if the cell had spent the rest of its existence getting ready for this moment in an ultimate act of survival. And there is a good reason for this: no space for mistakes. Problems in the distribution of chromosomes during cell division have been correlated with aneuploidy, a common feature observed in cancers and several birth defects, and the main cause of spontaneous abortion in humans. In this paper we critically review the mechanisms of anaphase chromosome motion that resisted the scrutiny of more than one hundred years of research as part of a tribute to the pioneering work of Miguel Mota.

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“…The concept of mitotic spindles established on the data of fixed preparations had led biologists into the misconception that nuclear membranes break down at the end of prophase and that spindles appear in the cytoplasm at metaphase with or without the aid of centrioles. This idea cannot hold true for mitosis in eukaryotes to-day (Wada 1950(Wada , 1966(Wada , 1969a(Wada , 1970b.…”

Section: Introductionmentioning

confidence: 99%