The Mechanism of Oral Melatonin Ameliorates Intestinal and Adipose Lipid Dysmetabolism Through Reducing Escherichia Coli-Derived Lipopolysaccharide

Rong, Bohan; Wu, Qiong; Reíter, Russel J.; Sun, Cheng

doi:10.1016/j.jcmgh.2021.06.024

Cited by 22 publications

(14 citation statements)

References 96 publications

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“…MT indirectly influences the gut microbiota through its properties as an antioxidant, immunomodulator, and circadian rhythm regulator, but also directly through mechanisms that warrant further research ( Figure 2 ). The latter was demonstrated using GF and antibiotic-treated models that managed to suppress the systemic effects of exogenous MT administration [ 83 , 84 ].…”

Section: Melatonin and The Gut Microbiome Interplaymentioning

confidence: 99%

Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions

et al. 2022

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Melatonin is a pineal indolamine, allegedly known as a circadian rhythm regulator, and an antioxidative and immunomodulatory molecule. In both experimental and clinical trials, melatonin has been shown to have positive effects in various pathologies, as a modulator of important biochemical pathways including inflammation, oxidative stress, cell injury, apoptosis, and energy metabolism. The gut represents one of melatonin’s most abundant extra pineal sources, with a 400-times-higher concentration than the pineal gland. The importance of the gut microbial community—namely, the gut microbiota, in multiple critical functions of the organism— has been extensively studied throughout time, and its imbalance has been associated with a variety of human pathologies. Recent studies highlight a possible gut microbiota-modulating role of melatonin, with possible implications for the treatment of these pathologies. Consequently, melatonin might prove to be a valuable and versatile therapeutic agent, as it is well known to elicit positive functions on the microbiota in many dysbiosis-associated conditions, such as inflammatory bowel disease, chronodisruption-induced dysbiosis, obesity, and neuropsychiatric disorders. This review intends to lay the basis for a deeper comprehension of melatonin, gut microbiota, and host-health subtle interactions.

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Section: Melatonin and The Gut Microbiome Interplaymentioning

confidence: 99%

Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions

et al. 2022

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“…Although it has not been proved that MT can successfully treat gut dysbiosis, another recent study demonstrated that oral MT is able to reduce the production of lipopolysaccharide (LPS) by intestinal Escherichia coli , therefore improving intestinal and adipose lipid dysmetabolism [ 167 ]. Considering that LPS plays an important role in the development of MS, it would be interesting to study whether MT is able to regulate gut dysbiosis.…”

Section: On Treatment Metabolically and Biochemically-derived Preclin...mentioning

confidence: 99%

Hydrogen Ion Dynamics as the Fundamental Link between Neurodegenerative Diseases and Cancer: Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis on Multiple Sclerosis

Harguindey¹,

Alfarouk

Orozco³

et al. 2022

IJMS

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The pH-related metabolic paradigm has rapidly grown in cancer research and treatment. In this contribution, this recent oncological perspective has been laterally assessed for the first time in order to integrate neurodegeneration within the energetics of the cancer acid–base conceptual frame. At all levels of study (molecular, biochemical, metabolic, and clinical), the intimate nature of both processes appears to consist of opposite mechanisms occurring at the far ends of a physiopathological intracellular pH/extracellular pH (pHi/pHe) spectrum. This wide-ranging original approach now permits an increase in our understanding of these opposite processes, cancer and neurodegeneration, and, as a consequence, allows us to propose new avenues of treatment based upon the intracellular and microenvironmental hydrogen ion dynamics regulating and deregulating the biochemistry and metabolism of both cancer and neural cells. Under the same perspective, the etiopathogenesis and special characteristics of multiple sclerosis (MS) is an excellent model for the study of neurodegenerative diseases and, utilizing this pioneering approach, we find that MS appears to be a metabolic disease even before an autoimmune one. Furthermore, within this paradigm, several important aspects of MS, from mitochondrial failure to microbiota functional abnormalities, are analyzed in depth. Finally, and for the first time, a new and integrated model of treatment for MS can now be advanced.

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“…Altogether, these data indicates that NO and caspase inhibition are theoretically indicated in AD, MS and also in other HNDDs [30,31] (sections 2.11 and 2.15) (Box 2). [148, [158][159][160][161][162][163] Nitric oxide (NO), inhibitors. [ 30,31,[191][192][193] Antilactacemics in MS. [ 15,194] 1.6.…”

Section: Cellular and Microenvironmental Acid-base Abnormalities In Neurodegenerative Diseases (Box 1)mentioning

confidence: 99%

“…Although it has not been proved that MT could be able to correct gut dysbiosis, another recent study demonstrates that oral MT is able to reduce the production of Lipopolysaccharide (LPS) by intestinal Escherichia coli, therefore improving intestinal and adipose lipid dysmetabolism [162]. Since LPS plays an important role in the development of MS, it would be interesting to study whether MT is able to regulate gut dysbiosis.…”

Section: Treating Microbiota In Neurodegenerationmentioning

confidence: 99%

Hydrogen Ion Dynamics as the Fundamental Link Between Neurodegenerative Diseases and Cancer. Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis in Multiple Sclerosis

Harguindey¹,

Alfarouk²,

Orozco³

et al. 2022

Preprint

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The pH-related metabolic paradigm has rapidly grown in cancer research and treatment. In this contribution, this recent oncological perspective has been laterally for the first time in order to integrate neurodegeneration within the energetics of the cancer acid-base conceptual frame. At all levels of study, molecular, biochemical, metabolic and clinical, the intimate nature of both processes appears to be opposite mechanisms occurring at the far ends of a physiopathological intracellular pH/extracellular pH (pHi/pHe) spectrum. This wide-ranged original approach now permits an increase in our understanding of these opposite processes, cancer and neurodegeneration, and, as a consequence, allows to propose new avenues of treatment based upon the intracellular and microenvironmental hydrogen ion dynamics regulating and deregulating the biochemistry and metabolism of both cancer and neural cells. Under the same perspective, the etiopathogenesis and special characteristics of multiple sclerosis (MS) becomes an excellent model for the study of neurodegenerative diseases and, utilizing this pioneering approach, we find that MS appears to be a metabolic disease even before an autoimmune one. Also within this paradigm, several important aspects of MS, from mitochondrial failure to microbiota functional abnormalities, are analyzed in depth.

show abstract

The Mechanism of Oral Melatonin Ameliorates Intestinal and Adipose Lipid Dysmetabolism Through Reducing Escherichia Coli-Derived Lipopolysaccharide

Cited by 22 publications

References 96 publications

Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions

Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions

Hydrogen Ion Dynamics as the Fundamental Link between Neurodegenerative Diseases and Cancer: Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis on Multiple Sclerosis

Hydrogen Ion Dynamics as the Fundamental Link Between Neurodegenerative Diseases and Cancer. Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis in Multiple Sclerosis

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