The mechanism of polymerisation of butyl cyanoacrylate in aqueous dispersions

Behan, Niall; Birkinshaw, C.

doi:10.1002/1521-3927(20000801)21:13<884::aid-marc884>3.0.co;2-5

Cited by 20 publications

(15 citation statements)

References 10 publications

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“…This trapped compound [12] modifies the osmotic pressure into the particles to counteract the Laplace pressure, and is called an 'osmotically' (or kinetically) stable emulsion or miniemulsion. Ostwald ripening could not be seen in any IPE systems [1][2][3][4][5], since the polymer chains that are generated through interfacial polymerisation act as this specific trapped species.…”

Section: Changing the Specific Surface Of The Emulsionmentioning

confidence: 99%

“…For several years now, our group [1-3] and others [4,5] demonstrated that the ionic polymerisation in emulsion (IPE) process could be applied to other monomers than cyclosiloxanes. Most studies focused on mechanistic aspects, a necessary step when dealing with a new type of polymerisation process.…”

Section: Introductionmentioning

confidence: 99%

“…Termination reaction of course involves water, and this process may be reversible (alkyl cyanoacrylates [3,4] or episulfides [5]) or not (phenyl glycidyl ether [2] and pmethoxystyrene (pMOS) [1]). In all cases, anyway, only low molar mass oligomers are produced.…”

Section: Introductionmentioning

confidence: 99%

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On the key role of the interface in the cationic polymerisation of p-methoxystyrene in miniemulsion

2003

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This paper presents the latest improvements, in terms of reactivity and molar masses, of the process of cationic polymerisation of p-methoxystyrene in miniemulsion, which was published previously [Cauvin et al., Macromolecules 2002, 35, 7919]. The formulation was adapted to change dramatically the specific surface and the polarity of the interface where the polymerisation takes place. Adding hexadecane permits to significantly decrease the particle diameter and thus to favour a faster polymerisation rate. In addition, droplets generated by sonication are ideally covered by the INISURF (initiator/surfactant) dodecylbenzenesulfonic acid and nucleate quantitatively (true miniemulsion polymerisation). Hexadecane addition finally ensures a better stability of the polymerised dispersion. A more hydrophobic acidic surfactant, though used at much smaller concentrations, again allowed increasing the polymerisation rate. Both systems, however, show no improvements in terms of molar masses compared to those observed previously. By separating the initiating agent (a super acid such as triflic acid) from the surfactant (a non-ionic one) an increase of molar masses is obtained but accompanied by an important drop of the polymerisation rate.

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Section: Changing the Specific Surface Of The Emulsionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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On the key role of the interface in the cationic polymerisation of p-methoxystyrene in miniemulsion

2003

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“…37 Throughout the polymerization process, hydroxyl ions in the medium initiated the reaction of monomeric units to form oligomers that were stabilized by the surfactant. 37,38 The freshly formed particles further absorbed monomer molecules until the monomer completely disappeared and gradually polymerized into nanosized particles. The hydroxyl ions present in the aqueous solution promoted the polymerization of the remaining monomers.…”

Section: Results and Discussion Preparation And Physicochemical Charamentioning

confidence: 99%

“…The hydroxyl ions present in the aqueous solution promoted the polymerization of the remaining monomers. 38 Concurrently, QT is a hydrophobic drug, which might have gradually dispersed in the hydrophobic part of the swollen micelles. It might have further been incorporated in polymer NPs by emulsion during the polymerization.…”

Section: Results and Discussion Preparation And Physicochemical Charamentioning

confidence: 99%

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Bagad¹,

Khan²

2015

IJN

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Background Quercetin (QT) is a potential bioflavonol and antioxidant with poor bioavailability and very low distribution in the brain. A new oral delivery system comprising of poly(n-butylcyanoacrylate) nanoparticles (PBCA NPs) was introduced to improve the oral bioavailability of QT and to increase its distribution in the brain. Physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80) were investigated. Objective This study aimed to investigate the physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80). Results The results showed that QT-PBCA NPs and QT-PBCA NPs coated with P-80 (QT-PBCA+P-80) had mean particle sizes of 161.1±0.44 nm and 166.6±0.33 nm respectively, and appeared spherical in shape under transmission electron microscopy. The mean entrapment efficiency was 79.86%±0.45% for QT-PBCA NPs and 74.58%±1.44% for QT-PBCA+P-80. The in vitro release of QT-PBCA NPs and QT-PBCA+P-80 showed an initial burst release followed by a sustained release when compared to free QT. The relative bioavailability of QT-PBCA NPs and QT-PBCA+P-80 enhanced QT bioavailability by 2.38- and 4.93-fold respectively, when compared to free QT. The biodistribution study in rats showed that a higher concentration of QT was detected in the brain after the NPs were coated with P-80. Conclusion This study indicates that PBCA NPs coated with P-80 can be potential drug carriers for poorly water-soluble drugs. These NPs were observed to improve the drugs’ oral bioavailability and enhance their transport to the brain.

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Polymerizations in Aqueous Dispersed Media

Charleux¹,

Ganachaud²

2007

Macromolecular Engineering

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The mechanism of polymerisation of butyl cyanoacrylate in aqueous dispersions

Cited by 20 publications

References 10 publications

On the key role of the interface in the cationic polymerisation of p-methoxystyrene in miniemulsion

On the key role of the interface in the cationic polymerisation of p-methoxystyrene in miniemulsion

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Polymerizations in Aqueous Dispersed Media

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