The mechanism of red blood cell aggregation investigated by means of direct cell manipulation using multiple optical trapping

Bronkhorst, P.J.H.; Brimbergen, J.; Nijhof, Evert-Jan; Brakenhoff, G. J.; Sixma, JJ

doi:10.1016/0006-355x(95)92117-s

Biorheology

1995

DOI: 10.1016/0006-355x(95)92117-s

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The mechanism of red blood cell aggregation investigated by means of direct cell manipulation using multiple optical trapping

P.J.H. Bronkhorst¹,

J. Brimbergen²,

Evert-Jan Nijhof³

et al.

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1998

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“…The principle of the new method is shown in figure 1a, which displays a tracing of human red blood cells dispersed in Isoton solution (Coulter, UK) (see Bronkhurst et al . 1997;Bongrand 1988).…”

mentioning

confidence: 99%

New theory and observations of cell adhesion

Kendall

Liang

Stainton

1998

Proc. R. Soc. Lond. A

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Over the years, attempts have been made to measure cell adhesion by several techniques, including, most recently, laser tweezers. Such tests have been used to interpret molecular theories of cell attachment and aggregation. However, the connection between adhering cells and molecular interactions is not fully understood. Here we define a new definition of cell adhesion which is exact and absolute at low cell concentrations. The idea is based on the statistical mechanics argument that particle bonding is directly related to the number of doublets existing in an ensemble. The theory is extended by computer modelling to high cell volume fractions. The benefit of this new theory is that it can be used in conjunction with cell counting machines, such as the Coulter counter, to obtain adhesion parameters directly, without applying any forces to the cells themselves. Experiments fitted the theory for human cells. The theory was also tested by using surface molecular treatments to alter the adhesive character of the cell suspension. Glutaraldehyde reduced adhesion, whereas dextran and fibronection increased adhesion of the red cells.

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mentioning

confidence: 99%

New theory and observations of cell adhesion

Kendall

Liang

Stainton

1998

Proc. R. Soc. Lond. A

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The mechanism of red blood cell aggregation investigated by means of direct cell manipulation using multiple optical trapping

Cited by 1 publication

References 0 publications

New theory and observations of cell adhesion

New theory and observations of cell adhesion

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