Rose, R. J. Some physiological and biochemical effects of the intravenous administration of five different electrolyte solutions in the dog. 1. vet. Pharnacol. Therap. 2, 279-289, 1979.Some physiological effects of the intravenous administration of five different commercial electrolyte solutions were studied in healthy conscious dogs. Measurements were taken before, during and up to 3 h after fluid administration. The measurements included temperature, heart rate, respiratory rate, systolic and diastolic arterial pressure, central venous pressure, p02, pC02, pH, packed cell volume, haemoglobin, total plasma protein, sodium, potassium, chloride, bicarbonate, base excess and creatinine. There were no significant changes in temperature, respiratory rate, systolic pressure, p 0 2 or pCOz. All dogs showed a similar rise in central venous pressure and a fall in packed cell volume, haemoglobin and total plasma protein in response t o the fluid administration. Two saline solutions produced a metabolic acidosis, a fall in plasma potassium values and a rise in chloride. Administration of multi-electrolyte solutions resulted in the least disturbance in acid-base and electrolyte balance.