The mechanism of the anomalous behavior of the plastic flow of materials with high crystal relief caused by the dynamic impurity subsystem

Petuhov, B. V.

doi:10.21883/pss.2022.14.54339.157

Cited by 1 publication

(1 citation statement)

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“…In this research, the capability of attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) combined with pattern recognition methods based on a Under conditions of high-intensity MI, the mass-produced defects and impurity atoms displaced from lattice junctions via the diffusion of intrinsic inter-node atoms to dislocations form "enriched" regions that determine the changes in SB properties-«dynamic strain aging» (DSA). It is shown [31] that the energy diagram representing the migration "relief" of defects and impurities also has a discontinuous periodic relationship with time "τ" shift per lattice period, with maxima and minima. The minima in the diagram corresponds to a decrease in the activation energy of the thermally activated jump to the dislocation nucleus, which is what allows the material to undergo DSA.…”

Section: Fourier-transform Infrared Spectroscopy Analysismentioning

confidence: 99%

Exploring the Effects of Cramped-Impact-Type Mechanical Action on Active Pharmaceutical Ingredient (Levofloxacin)—Prospects for Pharmaceutical Applications

Uspenskaya,

Simutina,

Kuzmina

et al. 2023

Powders

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Mechanochemistry is one of the ten great discoveries of green chemistry methods for synthesizing new substances. A drug substance from the fluoroquinolone group was exposed to high-intensity mechanical impacts using a laboratory knife mill for 21 min and constantly monitored by analyzing samples extracted every 3 min with DLS, SLS, LALLS, 2D-LS, optical and digital microscopy, FTIR, and Spirotox methods. A dispersity phenomenon was detected in an area where catastrophic dislocations formed and multiplied via laser methods. The positive correlation between the temperature of deformation and stress was demonstrated, similar to a typical stress–strain curve of a Bochvar–Oding curve and Young’s modulus: the angular coefficient of the straight section to OX was tgα = 10 min−1. Z-Average, ζ-potential, and polydispersity index dependences were represented as discontinuous periodic oscillations analogous to the defect and impurity transitions near the dislocation core. Deformation r from the high-intensity mechanical impact resulted in covalent bonds showing hyper- and hypochromic effects under FTIR spectra, a bathochromic shift of the maximum, and an oscillation emission at 3240 cm−1. A 2D-LS fingerprint diagram obtained via the topological convolution of the light scattering matrix made it possible to distinguish the off-loading samples from the native substance. The investigation of the dissolution kinetics in water via laser diffraction led to conclusions about the limiting diffusion stage and the acceleration of the mechanoactivation of the solid body’s dissolution under both linear and plastic deformation. The acceleration of obsEa of the cell death process in the temperature range from 296 to 302 K indicated a significant (2.5-fold) decrease in the toxicity of the aqueous 9 mM (1:3) sample solution at 21 min compared to that of the native levofloxacin. Adherence to the mechanochemistry laws provides an opportunity for drug repositioning to change their brand status by identifying new physicochemical and biological properties.

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Section: Fourier-transform Infrared Spectroscopy Analysismentioning

confidence: 99%