The mechanism of the drinking response to some hypotensive drugs: Activation of the renin-angiotensin system by direct or reflex-mediated stimulation of ?-receptors

Meyer, Dieter; Rauscher, W.; Peskar, B.; Hertting, G.

doi:10.1007/bf00500774

Cited by 36 publications

(18 citation statements)

References 21 publications

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“…Middle-aged and old rats did not have pronounced surges in drinking after the drugs and had greatly reduced renin levels compared with young rats. A likely explanation for drinking after isoproterenol and salbutamol is that ␤ 2 -adrenoceptor activation by the drugs causes vasodilation and reductions in arterial pressure that stimulate drinking by releasing renal renin (17,21,23,26,31). Signals arising from arterial baroreceptors in response to hypotension are postulated to stimulate drinking after isoproterenol (16,31).…”

Section: Discussionmentioning

confidence: 99%

“…Stimulation of vascular ␤ 2 -adrenergic receptors causes vasodilation and reductions in arterial pressure, which reflexively increase HR and renin secretion through baroreceptor mechanisms (21, 26). The water drinking response is a result of isoproterenol-induced hypotension and renin secretion (21,26,31).Several studies have used isoproterenol to examine agerelated declines in drinking by rats (24,25,34,35). However, the relative contributions of the ␤ 1 -and ␤ 2 -adrenergic receptor subtypes to age-related drinking have not been examined.…”

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confidence: 99%

“…Stimulation of myocardial ␤ 1 -adrenergic receptors increases heart rate (HR) (21,35) and strength of contraction (7,22). Activation of other ␤ 1 -adrenergic receptors located on the juxtaglomerular apparatus of the kidney releases renin (21,26). Stimulation of vascular ␤ 2 -adrenergic receptors causes vasodilation and reductions in arterial pressure, which reflexively increase HR and renin secretion through baroreceptor mechanisms (21,26).…”

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confidence: 99%

“…ISOPROTERENOL IS A MIXED ␤ 1 , ␤ 2 -adrenergic receptor agonist that causes hypotension (6,16,21,31,35), tachycardia (6,9,21), renin secretion (21,26), and water drinking (16,17,21,31) upon administration. The ␤ 1 and ␤ 2 receptor subtypes contribute differently to the effects of isoproterenol.…”

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confidence: 99%

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confidence: 99%

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Effects of β-adrenergic receptor agonists on drinking and arterial blood pressure in young and old rats

Thunhorst

Grobe²,

Beltz³

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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Thunhorst RL, Grobe CL, Beltz TG, Johnson AK. Effects of ␤-adrenergic receptor agonists on drinking and arterial blood pressure in young and old rats. Am J Physiol Regul Integr Comp Physiol 300: R1001-R1008, 2011. First published February 9, 2011 doi:10.1152/ajpregu.00737.2010.-These experiments examined water-drinking and arterial blood pressure responses to ␤-adrenergic receptor activation in young (4 mo), "middle-aged" adult (12 mo), and old (29 mo) male rats of the Brown-Norway strain. We used isoproterenol to simultaneously activate ␤1-and ␤2-adrenergic receptors, salbutamol to selectively activate ␤2-adrenergic receptors, and the combination of isoproterenol and the ␤2-adrenergic receptor antagonist ICI 118,551 to stimulate only ␤1-adrenergic receptors. Animals received one of the drug treatments, and water drinking was measured for 90 min. About 1 wk later, animals received the same drug treatment for measurement of arterial blood pressure responses for 90 min. In some rats, levels of renin and aldosterone secretion in response to isoproterenol or salbutamol were measured in additional tests. Old and middle-aged rats drank significantly less after isoproterenol than did young rats and also had greater reductions in arterial blood pressure. Old and middle-aged rats drank significantly less after salbutamol than did young rats, although reductions in arterial blood pressure were equivalent across the ages. The ␤2-adrenergic antagonist ICI 118,551 abolished drinking after isoproterenol and prevented most of the observed hypotension. Renin secretion after isoproterenol and salbutamol was greater in young rats than in middle-aged rats, and wholly absent in old rats. Aldosterone secretion was reduced in old rats compared with young and middle-aged rats after treatment with isoproterenol, but not after treatment with salbutamol. In conclusion, there are age-related differences in ␤-adrenergic receptor-mediated drinking that can be explained only in part by age-related differences in renin secretion after ␤-adrenergic receptor stimulation. aging; water intake; heart rate; renin activity; hematocrit; aldosterone ISOPROTERENOL IS A MIXED ␤ 1 , ␤ 2 -adrenergic receptor agonist that causes hypotension (6,16,21,31,35), tachycardia (6, 9, 21), renin secretion (21, 26), and water drinking (16, 17, 21, 31) upon administration. The ␤ 1 and ␤ 2 receptor subtypes contribute differently to the effects of isoproterenol. Stimulation of myocardial ␤ 1 -adrenergic receptors increases heart rate (HR) (21, 35) and strength of contraction (7,22). Activation of other ␤ 1 -adrenergic receptors located on the juxtaglomerular apparatus of the kidney releases renin (21, 26). Stimulation of vascular ␤ 2 -adrenergic receptors causes vasodilation and reductions in arterial pressure, which reflexively increase HR and renin secretion through baroreceptor mechanisms (21, 26). The water drinking response is a result of isoproterenol-induced hypotension and renin secretion (21,26,31).Several studies have used isoproterenol to examine agerelate...

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