The mechanism of the gut microbiota affecting the development of Alzheimer's disease and expectations on therapeutic methods

Abstract

Alzheimer's disease (AD) is the most common neurological disease that causes dementia, affecting millions of people every year. Recent studies have shown that there is a potential relationship between AD and gut microbiota. The changes of gut microbiota and their metabolites are related to neuroinflammation and can affect the disease progression of all stages of AD. This paper summarizes the changes of gut microbiota in each stage of AD, the mechanism of gut microbiota affecting the progression of AD and the means of treating AD by changing gut microbiota. This work may play an important role in the diagnosis and treatment of AD staging.