The Mechanism of the Production of Suppression of Urine in Blackwater Fever

Yorke, Warrington; Nauss, Ralph W.

doi:10.1080/00034983.1911.11686355

Cited by 52 publications

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“…Yorke and Nauss were the first to report suppression of urine following intravenous injections of hemoglobin into rabbits (2). Baker and Dodds confirmed this and ascribed the precipitation of the hemoglobin in the tubules to an acid urine (3).…”

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confidence: 99%

The Influence of Injections of Homologous Hemoglobin on the Kidneys of Normal and Dehydrated Animals

Lalich

1947

Journal of Experimental Medicine

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1. Dehydration, if sufficiently prolonged, favors the accumulation of hemoglobin or its derivatives in the kidneys of rabbits, principally casts formed in the distal convoluted tubules. 2. Once pigment casts have been produced in the distal convoluted tubules, there is obstruction, with atrophy and dilatation of the tubules proximal to the obstruction. 3. When the involvement is sufficiently extensive, there is elevation of the non-protein nitrogen and some animals die because of renal failure.

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confidence: 99%

The Influence of Injections of Homologous Hemoglobin on the Kidneys of Normal and Dehydrated Animals

Lalich

1947

Journal of Experimental Medicine

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“…Yorke and Nauss (1911) were able to produce renal obstruction by injection of haemoglobin into animals provided they were kept on a dry diet. They considered the obstruction was due to precipitation of acid haematin in the tubules from a concentrated urine.…”

Section: The Anuriamentioning

confidence: 99%

Blackwater Fever in West Africa

Skipper¹,

Haine²

1945

BMJ

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For a period of 20 months we were stationed at a general hospital in one of the West African colonies. This hospital was situated in well-drained uplands, its precincts being practically free of the anopheline mosquito, but within two miles the hills descended-into large areas of swampy ground where subtertian malaria was rife. Most of the cases of malaria and all the cases of blackwater fever treated in this hospital came from these areas. During the 20-month period 2,355 cases of subtertian malaria in British and Allied personnel were admitted, the majority being from the British Army. In the same interval 7 cases of blackwater fever were admitted. There were no deaths from either disease. Clinical FeaturesA full account of these may be found in standard works.The most important biochemica;l and other details of our cases are summarized in Tables I and II.

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“…Possibly there are other factors. Yorke and Nauss (1911) advanced the hypothesis that hemoglobin is excreted by the epithelial cells of the convoluted tubules which are damaged in the process. Deeks and James (1911) noted that "in all types at the onset of the attack there is some suppression of urine, followed as a rule by hypersecretion."…”

Section: Characteristics Of the Infectionmentioning

confidence: 99%

A Symposium on Human Malaria with Special Reference to North America and the Caribbean Region

1942

JAMA

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Facilities for blood film diagnosis A few public health labs. Central Lab.: 5 am¬ bulatory clinics since 1937 Government Lab. (Belize) Medical aid in only 16.2% of all deaths 1938 Fruit Company Hos¬ pitals in port cities have good labs. Public Health Labs. (15) & ambulatory clinics Public Health Labs. in San Jose; special surveys Methods of routine diagnosis 14 MALARIA Relative frequency species of malaria plasmodia6 P. falciparum P. vivax P. malariae P. vivax and P. falciparum about equal P. malariae (imported) P. falciparum 90.3% P. vivax 9.2% P. malariae 0.3% P. falciparum 65% P. vivax 32% P. malariae 3% No data; all three species present P. falciparum 55% P. vivax 43 %

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The Mechanism of the Production of Suppression of Urine in Blackwater Fever

Cited by 52 publications

References 0 publications

The Influence of Injections of Homologous Hemoglobin on the Kidneys of Normal and Dehydrated Animals

The Influence of Injections of Homologous Hemoglobin on the Kidneys of Normal and Dehydrated Animals

Blackwater Fever in West Africa

A Symposium on Human Malaria with Special Reference to North America and the Caribbean Region

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