The Mechanism of Zinc Sulfate in Improving Fertility in Obese Rats Analyzed by Sperm Proteomic Analysis

Ma, Jing; Han, Ruiyu; Li, Yuanlong; Cui, Tong; Wang, Shusong

doi:10.1155/2020/9876363

Cited by 7 publications

(8 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, its combination with ginger powder had a more significant effect than zinc alone. Our results were consistent with the results of previous studies (Ma et al, 2020; Schisterman et al, 2020) showing zinc supplementation greatly improves reproductive performance in people suffering from infertility. Our results showed that co‐administration of zinc with lead could improve tissue damage, sperm parameters and spermatogenesis process, and the pituitary‐gonadal axis activity.…”

Section: Discussionsupporting

confidence: 93%

The combination of ginger and zinc supplement could improve lead‐induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation

2022

View full text Add to dashboard Cite

Due to the growing industry and industrialization of many urban communities, one of the dangers that threaten human life is long‐term exposure to heavy metals such as lead. Lead contamination can have a detrimental effect on fertility. On the other hand, the combination of ginger and zinc supplements can be a powerful sexual enhancer. Despite extensive studies on the effect of ginger and zinc on reproduction, the effects of the combination of ginger and zinc supplement on lead‐induced reproductive dysfunction are not fully understood. Sixty‐four adult male rats were allocated into control, lead acetate (10 mg/kg), ginger (250 mg/kg), ginger–lead group, zinc (120 mg/kg) group, zinc–lead group, ginger–zinc group and ginger–zinc–lead group. The drugs were administrated by gavage for 4 weeks. The concentration of LH, FSH, testosterone, TNF‐α, IL‐1β, antioxidant enzyme activity, MDA, spermatogenesis, and sperm parameters were measured. The expression of NF‐kB, Nrf2, Bcl2, BAX, and Cas‐3 was evaluated. The histopathological assessment was also detected. Lead significantly could induce inflammation, apoptosis, and oxidative damage in testis tissue, and decrease hormonal levels, spermatogenesis, and sperm parameters compared to the control group (p < 0.05). While in reverse manner ginger, zinc, and their combination significantly improved all of them compared to the lead group (p < 0.05). These results were also supported by histological findings. It can be concluded that ginger, zinc, and their combination could prevent lead‐induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation and improve reproductive performance.

show abstract

Section: Discussionsupporting

confidence: 93%

The combination of ginger and zinc supplement could improve lead‐induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation

2022

View full text Add to dashboard Cite

show abstract

“…A study conducted on LC showed a significant increase in plasma testosterone level in male adult albino mice that were treated with cadmium chloride at dose 0.35 mg/kg [ 38 ]. Similarly, a study conducted on ZnSO 4 in improving fertility also supported that Zn had a positive effect on testosterone level and semen quality in infertile 7-week-old Sprague Dawley rats [ 39 ]. CoQ10 also reversed the testicular damage associated with cadmium toxicity by enhancing the levels of LH and testosterone in rodents likewise the present study [ 39 ].…”

Section: Discussionmentioning

confidence: 90%

“…Similarly, a study conducted on ZnSO 4 in improving fertility also supported that Zn had a positive effect on testosterone level and semen quality in infertile 7-week-old Sprague Dawley rats [ 39 ]. CoQ10 also reversed the testicular damage associated with cadmium toxicity by enhancing the levels of LH and testosterone in rodents likewise the present study [ 39 ].…”

Section: Discussionmentioning

confidence: 90%

Comparative Potential of Zinc Sulfate, L-Carnitine, Lycopene, and Coenzyme Q10 on Cadmium-Induced Male Infertility

Iftikhar

Akhtar

Saleem

et al. 2022

International Journal of Endocrinology

View full text Add to dashboard Cite

The human exposure to toxic chemicals and heavy metals is one of the main predisposing factors contributing to male infertility. Acute exposure to cadmium chloride results in testicular damage and infertility. The purpose of the present study was to investigate and compare the curative effect of coenzyme Q10 (CoQ10), lycopene, L-carnitine (LC), and zinc sulfate against the cadmium-induced infertility in male Wistar rats. Cadmium chloride (0.4 mg/kg/day) was orally administered to rats for three consecutive days. Then, oral administration of different treatments (i.e., LC 100 mg/kg, CoQ10 20 mg/kg, lycopene 4 mg/kg, zinc sulfate 6 mg/kg, and a combination LC-CoQ10 at 500/50 mg/kg) was carried out for 30 days. The impact of different treatments on semen parameters, such as sperm count and motility, testicular antioxidants, and serum testosterone, was determined. Furthermore, the morphology of epididymis sperms and histopathology of rat testes were also assessed. Cadmium exposure decreased the sperm count, progressive sperm motility, testosterone, superoxide dismutase (SOD), and catalase and reduced glutathione (GSH). It also caused banana sperm tail, bent sperm head, vacuolization of seminiferous tubules, and oligospermia in rat testes. All treatments with nutraceuticals improved sperm count, sperm morphology, serum testosterone, vacuolization of seminiferous tubules, and oligospermia in diseased rats. Treatment with lycopene, LC, and LC-CoQ10 improved progressive sperm motility and other parameters and increased SOD, GSH, and CAT in the rat testes. CoQ10 also increased SOD activity in rat testes’ tissue homogenates. It is concluded from the current study that all nutraceuticals partially improved reproductive toxicity of cadmium. The administration of lycopene and a high-dose combination of LC-CoQ10 were more efficacious in treating cadmium-induced infertility than other treatments. Treatment of cadmium-exposed rats with lycopene, LC, CoQ10, and LC-CoQ10 improved sperm count and motility through reduction of testicular oxidative stress and improving serum testosterone.

show abstract

“…Research has shown that Zn supplementation enhances the physical characteristics of semen, including ejaculate volume, sperm count, motility, seminal plasma antioxidants, and fertility rate (Amen and Muhammad 2016;Rahman et al 2014;El-Speiy and El-Hanoun 2013;Rafique et al 2010;Ghasemi et al 2009;Oliveira et al 2004;Maldjian et al 1998). Rats treated with Zn showed an increase in sperm count, sperm motility, and testosterone levels, as well as improved testicular structure and spermatogenesis abnormalities caused by obesity (Ma et al 2020). However, other studies have suggested no significant association between Zn and sperm quality (Eggert-Kruse et al 2002;Lin et al 2000).…”

Section: Discussionmentioning

confidence: 95%

Implication of apoptosis and oxidative stress in mitigation of ivermectin long-term hazards by zinc nanoparticles in male rabbits

El-Shobokshy

Abo-Samaha

Sahwan

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Ivermectin is the medication of choice for treating human onchocerciasis and is used in veterinary medicine to treat a variety of ectoparasites and endoparasites. This study was designed to investigate the effects of zinc nanoparticles (ZnNPs) on the fertility of male rabbits exposed to experimental ivermectin (IVM) intoxication. A total of 72 mature male rabbits were equally divided into 4 groups (n = 18). The first group (CTR) served as control; the second group (IVM) received subcutaneous injection of IVM (0.2 mg/kg body weight); the third group (ZnNPs) fed on zinc nanoparticles (60 mg/kg diet); and the fourth group (ZnNPs + IVM) were administered IVM and zinc nanoparticles at the same doses. The experiment lasted for 9 weeks. Results revealed that IVM-intoxicated rabbits showed impaired growth performance parameters, including body weight, total body weight gain (TBWG), total feed intake (TFI), and feed conversion ratio (FCR). Moreover, carcass characteristic and fertility parameters (including semen quality parameters and testosterone levels) were also impaired after IVM administration. Additionally, testicular malondialdehyde (MDA) and antioxidant (reduced glutathione, superoxide dismutase, catalase) levels as well as the histopathology and immunohistochemical expression of caspase 3 and PCNA in the testes and epididymis were detrimentally affected. On the contrary, ZnNP administration efficiently improved most of these parameters in IVM-intoxicated rabbits. In conclusion, ZnNPs exhibited promising ability for improving the growth and fertility status of rabbits and reducing the deleterious effects of IVM possibly through the suppression of apoptotic and oxidative pathways. Graphical Abstract

show abstract

The Mechanism of Zinc Sulfate in Improving Fertility in Obese Rats Analyzed by Sperm Proteomic Analysis

Cited by 7 publications

References 48 publications

The combination of ginger and zinc supplement could improve lead‐induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation

The combination of ginger and zinc supplement could improve lead‐induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation

Comparative Potential of Zinc Sulfate, L-Carnitine, Lycopene, and Coenzyme Q10 on Cadmium-Induced Male Infertility

Implication of apoptosis and oxidative stress in mitigation of ivermectin long-term hazards by zinc nanoparticles in male rabbits

Contact Info

Product

Resources

About