The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice

Meng, Xiannan; Zhang, Ling; Hou, Jiwei; Ma, Tan; Pan, Chun Hsu; Zhou, Yuan; Han, Ruitong; Ding, Yuanzhen; Peng, Haoran; Zou, Xiang; Li, Dongmei; Han, Xiaodong

doi:10.1016/j.scitotenv.2020.139678

Cited by 17 publications

(5 citation statements)

References 73 publications

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“…Although the Chinese government has been controlling cyanobacteria blooms in Taihu Lake for a long time, they are still rampant, which have drawn the attention of the World Health Organization ( 24 ). Although we are not directly exposed to MCs, they can enter the human body through the consumption of aquatic animals, including fish, frogs, plankton or aquatic plants, and are finally distributed in various organs of the body ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Water Blooms—A Potential Threat to Male Reproduction: Clues From Aquatics and Rodents

Liu

2022

Front. Endocrinol.

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Toxic cyanobacteria blooms are a potential threat to global aquatic ecosystems and human health. Microcystin-leucine-arginine (MC-LR) is the most toxic variant of microcystins (MCs), and exposure to MCs can damage the male reproductive system. Two electronic databases were searched for controlled studies of rodents and fishes published before September 2020. Effect sizes were calculated for eight main reproductive parameters, including sperm count, sperm motility, sperm morphology, serum testosterone, testis weight, serum follicle stimulating hormone (FSH), serum luteinising hormone (LH) and serum estradiol. Nine meta-analyses of individual parameters were conducted using R version 4.0.2. Fifteen studies were included in the meta-analysis. In the studies of rodents, exposure to MC-LR by intraperitoneal injection or intragastric administration yielded statistically significant effects on sperm count (standardised mean difference (SMD) = -1.7426 (95% CI: -2.2098 to -1.2754)), abnormal sperm rate (SMD = 1.6714 (95% CI: 0.9702 to 2.3726)), sper5% CI: -3.9811 to -1.7834)), testis weight (SMD = -2.8822 (95% CI: -3.9811 to -1.7834)) and serum FSH (SMD = 0.4707 (95% CI: 0.0659 to 0.8756) changes in serum testosterone (SMD = 0.5521 (95% CI: 0.1652; 0.9391)) and estradiol (SMD = 0.6398 (95% CI: 0.1896 to 1.0900)) concentrations are considered to be statistically significant. Dose–response analysis reflected the dynamic changes of male reproductive function caused by MC. Short-term exposure to MC-LR can affect the function of the male reproductive system in rodents and fish. Elevated dosage or extended exposure time may worsen the damage. Human-related research on MC-LR exposure is very necessary to protect health and the water environment.

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Section: Discussionmentioning

confidence: 99%

Water Blooms—A Potential Threat to Male Reproduction: Clues From Aquatics and Rodents

Liu

2022

Front. Endocrinol.

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“…Although the Chinese government has been controlling cyanobacteria blooms in Taihu Lake for a long time, they are still rampant, which have drawn the attention of the World Health Organization (Wang et al 2013). Although we are not directly exposed to MCs, they can enter the human body through the consumption of aquatic animals, including sh, frogs, plankton or aquatic plants, and nally distributed in various organs of the body (Meng et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Water Blooms—A Potential Threat to Male Reproduction: Clues from Fishes and Rodent

Chen

Zhang

et al. 2021

Preprint

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Toxic cyanobacteria blooms are a potential threat to global aquatic ecosystems and human health. Microcystin-leucine-arginine (MC-LR) is the most toxic variant of microcystins (MCs), and exposure to MCs can damage the male reproductive system.Two electronic databases were searched for controlled studies of rodents and fishes published before September 2020. Effect sizes were calculated for eight main reproductive parameters, including sperm count, sperm motility, sperm morphology, serum testosterone, testis weight, serum follicle stimulating hormone (FSH), serum luteinising hormone (LH) and serum estradiol. Nine meta-analyses of individual parameters were conducted using R version 4.0.2. Fifteen studies were included in the meta-analysis. In the studies of rodents, exposure to MC-LR by intraperitoneal injection or intragastric administration yielded statistically significant effects on sperm count (standardised mean difference (SMD) = -1.7426 (95% CI: -2.2098 to -1.2754)), abnormal sperm rate (SMD = 1.6714 (95% CI: 0.9702 to 2.3726)), sperm motility (SMD = -2.8822 (95% CI: -3.9811 to -1.7834)), testis weight (SMD = -2.8822 (95% CI: -3.9811 to -1.7834)) and serum FSH (SMD = 0.4707 (95% CI: 0.0659 to 0.8756)). In fish studies, the changes in serum testosterone (SMD = 0.5521 (95% CI: 0.1652; 0.9391)) and estradiol (SMD = 0.6398 (95% CI: 0.1896 to 1.0900)) concentrations are considered to be statistically significant. Dose–response analysis reflected the dynamic changes of male reproductive function caused by MC. Short-term exposure to MC-LR can affect the function of the male reproductive system in rodents and fish. Elevated dosage or extended exposure time may worsen the damage. Human-related research on MC-LR exposure is very necessary to protect health and the water environment.

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“…A murine study on water pollutants reported that the offspring of male mice exposed to the water pollutant, microcystin-leucine arginine (MC-LR), via drinking water before conception showed growth deficits and thickened alveolar walls, as well as collagen deposition in the lungs at postnatal day 180 [ 58 ]. Paternal sperm piwi-interacting RNAs (piRNAs) were mostly downregulated, and the predicted targets were involved in the regulation of the embryo implantation pathways.…”

Section: Preconception Exposures and Respiratory Health: Evidence From Multigeneration Studies On Humansmentioning

confidence: 99%

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

López-Cervantes

Lønnebotn

Jõgi

et al. 2021

IJERPH

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Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept.

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The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice

Cited by 17 publications

References 73 publications

Water Blooms—A Potential Threat to Male Reproduction: Clues From Aquatics and Rodents

Water Blooms—A Potential Threat to Male Reproduction: Clues From Aquatics and Rodents

Water Blooms—A Potential Threat to Male Reproduction: Clues from Fishes and Rodent

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

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