The mechanisms of action of prenylated xanthones against breast, colon, and lung cancers, and their potential application against drug resistance

Gunter, Natalie Vivien; Teh, Soek Sin; Jantan, Ibrahim; CESPEDES-ACUÑA, Carlos Leonardo Armando; Mah, Siau Hui

doi:10.1007/s11101-022-09846-9

Cited by 7 publications

(1 citation statement)

References 101 publications

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“…The study of the dichloromethane: methanol (1:1) extract of dinde bark has allowed the identification of diprenylated xanthones: macluraxanthone B 43, macluraxanthone C 44, gartanin 45, and 8-desoxygartanin 46 (Groweiss et al 2000). In general, some compounds of this type, exhibit anti-inflammatory effects (Xue et al 2020), antiproliferative activity against breast, colon, and lung cancer cells (Gunter et al 2022), protective potential of intestinal barrier integrity in HT-29 cells (Tocmo et al 2021), and act as inhibitors of lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells (Jo et al 2017). A review of articles (PubChem) discussing the relationship between diprenylated xanthones identified in dinde and their biological effects indicates that macluraxanthone B 43 and macluraxanthone C 44 exhibit moderate in vitro antiviral activity against HIV (Pham et al 2020), while gartanin 45 inhibits the growth of prostate cancer lines via autophagy initiation (Kim et al 2015;Luo et al 2017), exhibits an antiproliferative effect in T98G cells (Gao et al 2016), and exerts neuroprotective effects (Dai and Mumper 2010), among other bioactivities.…”

Section: Xanthonesmentioning

confidence: 99%

Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

Quintero-Rincón,

Pájaro-González,

Diaz-Castillo

2024

ADV TRADIT MED (ADTM)

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Maclura tinctoria (Moraceae), commonly known as dinde, is a lactescent tree of significant economic importance with extensive ethnomedicinal and ethnobotanical applications. Among native populations in the Neotropics, dinde is used to address diverse forms of inflammatory arthritis, along with ailments stemming from viral, bacterial, or fungal origins. Its efficacy stands out notably in the treatment of conditions affecting the buccal cavity, respiratory tract, and venereal infections. These medicinal attributes have spurred investigations into their potential for developing nutraceuticals and pharmacological agents. Also, dinde has a commercial appeal intertwined with the remarkable qualities of its wood, which include the resistance to moisture and termites. This review consolidates information encompassing peer-reviewed articles from major scientific databases such as Science Direct, Scopus, Springer, PubMed, and Google Scholar. The review spans fifty-four phytocompounds, characterized by remarkable structural complexity and identified from the year 2000 onward. These compounds are categorized into flavones, isoflavones, flavonols, flavanols, flavanones, chalcones, and xanthones, where a significant portion exhibiting glycosylation or prenylation. Additionally, phenolic acids and condensed tannins contribute to the chemical diversity of this species. This comprehensive review offers updated insights into the potential bioactivity of chemical constituents identified in this plant, elucidating findings derived from different studies employing both in vitro and in vivo assays. Graphical abstract

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Section: Xanthonesmentioning

confidence: 99%

Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

Quintero-Rincón,

Pájaro-González,

Diaz-Castillo

2024

ADV TRADIT MED (ADTM)

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Synthetic and Natural Xanthones as Antibacterial Agents—Review

Prathiksha,

Murali,

Nayak

2024

ChemistrySelect

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Xanthones, a class of polyketide derivatives characterized by a dibenzo‐γ‐pyrone core structure, are aromatic oxygenated cyclic compounds extensively found in nature. They are known for their diverse biological activities, including anti‐Alzheimer, antitumor, and antidiabetic properties, which have spurred extensive research into their therapeutic potential. One of the most significant challenges facing mankind currently is the development of antibiotic resistance in pathogenic microbes making microbial infections increasingly difficult to treat. The formation of biofilms enhances bacterial resistance to antibiotics, immune defenses, and environmental stresses. In this review, we have categorized xanthones, both of biological origin and synthesized, based on their structure and summarized the recent studies on their ability to inhibit Gram‐positive and ‐negative bacteria as well as the various underlying mechanisms that contribute to their microbicidal activity. These mechanisms include inhibition of virulence factors and biofilm formation, interaction with cell membranes, and interference with cell wall synthesis and DNA replication. In addition, we have listed the various methods involved in biofilm inhibition and the structure‐activity relationship of various xanthone molecules, highlighting how xanthone derivatives exhibit increased antibacterial activity. With the growing concern of antibiotic resistance, exploring natural compounds like xanthones to study their interaction with bacterial cells is crucial for identifying new treatment options.

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A systematic review on understanding the mechanistic pathways and clinical aspects of natural CDK inhibitors on cancer progression.: Unlocking cellular and biochemical mechanisms

Asghar,

Chohan,

Khurshid

et al. 2024

Chemico-Biological Interactions

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The mechanisms of action of prenylated xanthones against breast, colon, and lung cancers, and their potential application against drug resistance

Cited by 7 publications

References 101 publications

Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

Synthetic and Natural Xanthones as Antibacterial Agents—Review

A systematic review on understanding the mechanistic pathways and clinical aspects of natural CDK inhibitors on cancer progression.: Unlocking cellular and biochemical mechanisms

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