The Mechanisms of Heart Failure Development in Obesity

Гриценко, О. В.; Чумакова, Г. А.; Шевляков, И. В.; Трубина, Е. В.

doi:10.15829/1560-4071-2018-5-81-86

Cited by 14 publications

(9 citation statements)

References 21 publications

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“…Many studies have confirmed that overweight / obesity entails both structural and functional changes in the heart itself, affects blood volume and ejection fraction, resulting in an increase of diastolic pressure. The formula for calculating the adaptive potential, proposed by R. M. Baevsky in 1987, includes not only hemodynamic parameters (blood pressure, heart rate), but also structural and metabolic parameters (height, weight), which are also indicators of the body's adaptive reserve [7].…”

Section: Figure 1 the Structure Of The Adaptive Potential Of Female Workers In The Agro-industrial Complex In Thementioning

confidence: 99%

The adaptive potential of workers in greenhouse farms in the Voronezh region

Yatsenko¹,

Dzen²,

Gabbasova³

et al. 2021

Наука России: Цели И Задачи

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Adaptive potential is an indicator of the level of adaptability of the human body to various and changing environmental factors. The adaptive capabilities of the body are influenced not only by external factors, but also by internal - the state of the body as a whole, by the presence or absence of chronic diseases. Therefore, the adaptive potential was used as an integral indicator of a person's adaptability to production factors. The aim of the study was to assess the adaptive capabilities of the organism of workers in greenhouse farms in the Voronezh region. The study was carried out at the enterprises of the closed ground of the region by the method of questioning, the objects of the study were 125 women aged 27-45 years. In most cases, there are violations of the adaptive capabilities of the organism among the studied workers of greenhouse farms, and even a breakdown in adaptation was revealed in 0.8%. In less than half of the cases, the adaptive potential of the greenhouses was within the normal. The adaptive reserves of the greenhouses workers decrease with age.

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Section: Figure 1 the Structure Of The Adaptive Potential Of Female Workers In The Agro-industrial Complex In Thementioning

confidence: 99%

The adaptive potential of workers in greenhouse farms in the Voronezh region

Yatsenko¹,

Dzen²,

Gabbasova³

et al. 2021

Наука России: Цели И Задачи

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“…Hypoadiponectinemia has been proved to promote LV myocardial hypertrophy, for, with adiponectin level being normal, adenosine monophosphate is activated and, in turn, activates protein kinase and suppresses α-adrenoreceptorstimulated cardiomyocyte hypertrophy. By hampering apoptosis, adiponectin has been shown to exhibit an anti-proliferative effect -incidentally, in all the tissues of the human body [1], [19].…”

Section: Adiponectinmentioning

confidence: 99%

“…Modern medicine regard obesity not only as a chronic metabolic disease leading to excessive fat accumulation but also as an independent risk factor for the development of cardiovascular diseases (CVDs). Numerous studies have shown obesity to result in both structural and functional cardiac alterations that lead to the left ventricle (LV) hypertrophy, rhythmic and conduction disorders, and diastolic dysfunction; and marked morbid disorder, also to cause LV systolic dysfunction, which is certainly conducive to chronic heart failure (CHF) advancement [1], [2]. A determinant mechanism behinds the development of that the condition is cardiovascular system (CVS) remodeling that results from hemodynamic and hormonal metabolic alterations caused by excessive accumulation of adipose tissue in the human body [3].…”

Section: Introductionmentioning

confidence: 99%

The Role of Adipokines in Cardiovascular Pathology

Подзолков

Pokrovskaya

Bazhanova

et al. 2021

Open Access Maced J Med Sci

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The recent decades saw a steady growth of obesity incidence worldwide. Obesity is an independent risk factor for cardiovascular diseases (CVDs) and type 2 diabetes mellitus and is also associated with a shorter life expectancy. Not only hemodynamic but also hormone metabolic processes, arising from excessive accumulation of adipose tissue in human body, underlie the development of CVDs. Adipose tissue has now been proved to be a hormone-active substrate. Studies of the influence of adipokines will bring us closer to understanding cardiovascular pathogenesis and help personalize prophylactic strategies.

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“…Существует гипотеза, что если утолщение стенки неадекватно мало по сравнению с нарастанием дилатации полости ЛЖ, то напряжение стенки ЛЖ длительное время остается повышенным. Это ведет к развитию систолической дисфункции и появлению признаков сердечной недостаточности [37].…”

Section: Obesity Impact On the Cardiovascular System влияние ожиренияunclassified

Obesity and Mechanisms of its Negative Impact on the Cardiovascular System

Miklishanskaya

Solomasova

Mazur

2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Currently, the number of obese people in the world is constantly increasing. Obesity has a direct negative impact on the heart and blood vessels, which can be considered not only as an appropriate response to an increase in the volume of circulating blood due to an increase in body weight, but also as a side tissue reaction of the myocardium to hormonal and metabolic changes inherent in obesity. Our review is devoted to the description of the mechanisms of influence of obesity on the structural and functional parameters of the heart, which create prerequisites for the development of cardiovascular diseases, as well as the existing contradictions. Currently, the accumulated data suggest that an excessive amount of adipose tissue, in addition to metabolic disorders, including insulin resistance, imbalance of adipokines and inflammation markers, leading to the development of lipotoxicity, can directly penetrate the myocardium and cause violations of its contractile properties, as well as affect the conduction of excitation pulses and provoke the development of rhythm and conduction disorders. The development of endothelial dysfunction in obesity ultimately leads to the development of atherosclerosis and coronary heart disease. In addition, obesity contributes to the emergence of risk factors for hypertension, diabetes, atrial fibrillation, chronic heart failure, obstructive sleep apnea syndrome. Given the differences in the literature on the effect of obesity on long-term outcomes in patients with cardiovascular diseases, it is important to conduct prospective studies on the role of individual factors and their combinations that affect the mortality of patients with cardiovascular diseases.

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The Mechanisms of Heart Failure Development in Obesity

Cited by 14 publications

References 21 publications

The adaptive potential of workers in greenhouse farms in the Voronezh region

The adaptive potential of workers in greenhouse farms in the Voronezh region

The Role of Adipokines in Cardiovascular Pathology

Obesity and Mechanisms of its Negative Impact on the Cardiovascular System

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