The Mechanoreception in Drosophila melanogaster Oocyte under Modeling Micro- and Hypergravity

Ogneva, Irina V.

doi:10.3390/cells12141819

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…[ 33,34 ] Additionally, scientists have made significant progress in developing bio‐inspired artificial skins capable of performing specific functions. [ 35–39 ] Furthermore, the understanding of the mechanical instability phenomenon can help elucidate the morphogenesis in cells or tissues as they grow under the influence of gravity, [ 40–48 ] potentially leading to advancements in tissue engineering and regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

Harnessing Gravity‐Induced Instability of Soft Materials: Mechanics and Application

Lü,

Li,

et al. 2024

Adv Funct Materials

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This work offers a comprehensive overview of how gravity affects soft materials, with a particular emphasis on gravity‐induced instability. Soft materials, including biological tissues, elastomers, and gels, are characterized by low elastic moduli and the ability to undergo significant deformations. These large deformations can lead to instabilities and the emergence of distinctive surface patterns when even small perturbations are introduced. An in‐depth understanding of these gravity‐induced instabilities in soft materials is of paramount importance for both fundamental scientific research and practical applications across diverse domains. The underlying mechanisms governing these instabilities are delved in and elucidate the techniques employed to study and manipulate them. Further, the gravity‐induced wrinkling and the Rayleigh‐Taylor (RT) instability in soft materials are zoomed in, highlighting how altered gravity environments impact natural and synthetic systems. Lastly, current and potential applications are underscored where gravity‐induced instabilities are already making an impact or may hold promise in the near future. In sum, the exploration of gravity‐induced instabilities in soft materials paves the way for innovative applications and advancements in a wide range of fields.

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Section: Introductionmentioning

confidence: 99%

Harnessing Gravity‐Induced Instability of Soft Materials: Mechanics and Application

Lü,

Li,

et al. 2024

Adv Funct Materials

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The Administration of Phospholipids with Polyunsaturated Fatty Acids in the Tail Groups Makes It Possible to Prevent the Decrease of Sperm Motility of the Fruit Fly Drosophila melanogaster in the Early Period of Readaptation after Space Flight

Ogneva,

Gogichaeva,

Zhdankina

et al. 2024

Biofizika

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The aim of the study was the attempt to prevent the decrease in sperm motility of the fruit fly Drosophila melanogaster that occurs in the early period of readaptation after space flight by adding phospholipids with polyunsaturated fatty acids in the tail groups (essential phospholipids) to the nutrient medium. The study was carried out as part of space flights on board the russian segment of the International space station during the period September 15, 2023 – September 27, 2023 (ISS-69) and March 23, 2024 – April 6, 2024 (ISS-70). The content of cytoskeletal proteins in the testes was determined by Western blotting and sperm motility by video recording and subsequent analysis. The results of the study show that modification of the nutrient medium by adding essential phospholipids leads to a decrease in cholesterol content and an increase in actin content, which prevents a decrease in tubulin content and a decrease in the speed of movement of fruit fly sperm in the early period of readaptation (up to 16 hours) after space flight. The data obtained, on the one hand, demonstrate a possible mechanism for triggering mechanotransduction, and on the other, allow us to propose essential phospholipids as one of the means of protection against negative changes associated with changes in the gravity field acting on the cell.

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Administration of Essential Phospholipids Prevents Drosophila Melanogaster Oocytes from Responding to Change in Gravity

Gogichaeva,

Ogneva

2024

Cells

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The aim of this study was to prevent initial changes in Drosophila melanogaster oocytes under simulated weightlessness and hypergravity at the 2 g level. Phospholipids with polyunsaturated fatty acids in the tail groups (essential phospholipids) at a concentration of 500 mg/kg of nutrient medium were used as a protective agent. Cell stiffness was determined using atomic force microscopy, the change in the oocytes’ area was assessed as a mark of deformation, and the contents of cholesterol and neutral lipids were determined using fluorescence microscopy. The results indicate that the administration of essential phospholipids leads to a decrease in the cholesterol content in the oocytes’ membranes by 13% (p < 0.05). The stiffness of oocytes from flies that received essential phospholipids was 14% higher (p < 0.05) and did not change during 6 h of simulated weightlessness or hypergravity, and neither did the area, which indicates their resistance to deformation. Moreover, the exposure to simulated weightlessness and hypergravity of oocytes from flies that received a standard nutrient medium led to a more intense loss of cholesterol from cell membranes after 30 min by 13% and 18% (p < 0.05), respectively, compared to the control, but essential phospholipids prevented this effect.

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The Mechanoreception in Drosophila melanogaster Oocyte under Modeling Micro- and Hypergravity

Cited by 4 publications

References 47 publications

Harnessing Gravity‐Induced Instability of Soft Materials: Mechanics and Application

Harnessing Gravity‐Induced Instability of Soft Materials: Mechanics and Application

The Administration of Phospholipids with Polyunsaturated Fatty Acids in the Tail Groups Makes It Possible to Prevent the Decrease of Sperm Motility of the Fruit Fly Drosophila melanogaster in the Early Period of Readaptation after Space Flight

Administration of Essential Phospholipids Prevents Drosophila Melanogaster Oocytes from Responding to Change in Gravity

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