The Medial Prefrontal Cortex (mPFC) and Addictions

Pérez-Rando, Marta; Guirado, Ramón

doi:10.1007/978-3-030-92392-1_25

Cited by 1 publication

(2 citation statements)

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“…The mPFC has been implicated in social behaviours and processing social information as well as the consequences of social isolation [ 29 , 30 , 80 , 81 ]. Socially isolated animals may exhibit alterations in mPFC activity, connectivity, and gene expression [ 82 ], leading to changes in the structure and function of the mPFC [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, social isolation is a significant risk factor for the development and maintenance of addiction in humans [ 83 ] as individuals lacking positive social connections and support systems might turn to drugs or other substances as a way to cope with loneliness, stress, or negative emotion [ 84 ]. The mPFC plays a critically important role in addiction in animal models, too [ 30 , 81 ] in line with its role in reward processing and decision-making [ 85 ]. The present study found that 10 days of social isolation alters the expression of genes in the mPFC involved in addiction suggesting the mPFC potentially contributes to the promotion of addiction by social isolation.…”

Section: Discussionmentioning

confidence: 99%

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Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex

Csikós,

Dóra,

Láng

et al. 2024

Cells

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(1) Background: The effects of short-term social isolation during adulthood have not yet been fully established in rats behaviourally, and not at all transcriptomically in the medial prefrontal cortex (mPFC). (2) Methods: We measured the behavioural effects of housing adult male rats in pairs or alone for 10 days. We also used RNA sequencing to measure the accompanying gene expression alterations in the mPFC of male rats. (3) Results: The isolated animals exhibited reduced sociability and social novelty preference, but increased social interaction. There was no change in their aggression, anxiety, or depression-like activity. Transcriptomic analysis revealed a differential expression of 46 genes between the groups. The KEGG pathway analysis showed that differentially expressed genes are involved in neuroactive ligand-receptor interactions, particularly in the dopaminergic and peptidergic systems, and addiction. Subsequent validation confirmed the decreased level of three altered genes: regulator of G protein signalling 9 (Rgs9), serotonin receptor 2c (Htr2c), and Prodynorphin (Pdyn), which are involved in dopaminergic, serotonergic, and peptidergic function, respectively. Antagonizing Htr2c confirmed its role in social novelty discrimination. (4) Conclusions: Social homeostatic regulations include monoaminergic and peptidergic systems of the mPFC.

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