Background: The mental health of individuals is an effective factor in having harmonious communication with others and changing and improving personal and social environments. This study aimed to investigate the relationship between primary incompatible patterns, cognitiveemotional regulation, and the mental health of operating room technologists in educational therapeutic centers in West Azerbaijan province, Iran. Methods: This cross-sectional descriptive-analytical study consisted of all operating room technologists working in educational centers in West Azerbaijan province. The inclusion criteria were technologists who had no history of mental illness diagnosed by a psychiatrist. The sample consisted of 123 people who were selected by simple random sampling. The data were collected using several demographic data forms, including the Early Maladaptive Schema Questionnaire, the Cognitive-Emotional Regulation Questionnaire (CERQ), and the Mental Health Questionnaire. The obtained data were analyzed by descriptive and inferential statistical tests, including the Kolmogorov-Smirnov test and Spearman correlation in SPSS 20 software. Results: The results showed a direct relationship between early maladaptive schemas and mental health (r=0.37, P<0.05), as well as between emotional cognitive regulation and mental health (r=0.30, P<0.05). A significant difference was found between emotional cognitive adjustment with age (r=0.12, P<0.05) and work experience (r=0.14, P<0.05), as well as between mental health and employment status (r=0.07, P<0.05). There was a direct and significant relationship. Conclusion: Based on the results, a direct and significant relationship was observed between early maladaptive schemas, emotional cognitive regulation, and the mental health of operating room technologists.