The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects

Santo, Francesco Dal; Carballo, Juan J.; Velasco, Ángela; Jiménez-Treviño, Luís; Rodríguez-Revuelta, Julia; Martínez-Cao, Clara; Caro-Cañizares, Irene; Fuente-Tomás, Lorena de la; Menéndez-Miranda, Isabel; González‐Blanco, Leticia; García-Portilla, M.P.; Bobes, Julio; Sáiz, Pilar A.

doi:10.3389/fpsyt.2020.538172

Cited by 9 publications

(4 citation statements)

References 52 publications

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“…Our results are congruent with a study reporting a positive major indirect effect of ACEs on suicidality through impulsivity among adolescents in Finland [21]. Similarly, a 2020 survey suggested that impulsivity mediate the childhood trauma effect on suicidal behavior in patients with major depressive disorder in Spain [76]. Specifically, the indirect effect of childhood physical abuse on suicidality via attentional impulsivity was significant among patients with bipolar disorder in Greece [77].…”

Section: Discussionsupporting

confidence: 90%

Intra-Familial Adverse Childhood Experiences and Suicidal Behaviors among Tunisian Youth: The Mediating Effects of Impulsivity and Resilience

Mlouki,

Abbes,

Hariz

et al. 2023

Understanding Child Abuse and Neglect - Research and Implications

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Given that resilience is the ability to cope with adversities, and impulsivity is characterized with rapid reactions without foresight, we aimed to explore the pathways between intra-familial childhood adversities, resilience, impulsivity and suicidal behaviors among adolescents in Mahdia and Gafsa cities (Tunisia). We conducted a cross-sectional study in secondary schools from January to February 2020. Exposure to intra-familial early life experiences was evaluated by the Adverse Childhood Experiences (ACEs)-International Questionnaire. Resilience and impulsivity were assessed via the Adolescent Psychological Resilience and the Barratt Impulsivity Scale. A total of 3170 students were recruited with a response rate of 74%. About 81.1% of them reported being emotionally abused. The resilience mean score was 86.10 ± 9.85. Impulsivity was screened among 42.2% of them. About 38% of students presented suicidal thoughts, 16.4% had a suicide plan, and 10.8% have made a suicide attempt. We found that exposure to intra-familial ACEs predicts suicidal behaviors through impulsiveness (% mediated = 18% for emotional violence) and interpersonal resilience (% mediated = 24% for emotional violence; % mediated = 20.4% for physical violence). Our results emphasize the need to prevent ACEs, and to seek out a way to promote ACE protective factors among adolescents such as resilience.

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Section: Discussionsupporting

confidence: 90%

Intra-Familial Adverse Childhood Experiences and Suicidal Behaviors among Tunisian Youth: The Mediating Effects of Impulsivity and Resilience

Mlouki,

Abbes,

Hariz

et al. 2023

Understanding Child Abuse and Neglect - Research and Implications

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“…Early life stress (ELS), such as physical abuse, sexual abuse, emotional abuse, physical neglect, and emotional neglect, are known as significant risk factors for many adverse health problems during adulthood [3][4][5] and are associated with physical illnesses such as diabetes, cardiovascular disease, and malignant tumor [6][7][8]. Exposure to ELS is a significant risk factor for mental illnesses such as major depressive disorder (MDD), schizophrenia, bipolar disorder, borderline personality disorder, posttraumatic stress disorder (PTSD), and substance use [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. The number of early life adverse experiences is also correlated with the increased risk of depression during adulthood.…”

Section: Introductionmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

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Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.

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“…Several studies have previously identified impulsivity as a risk factor for suicidal behaviors in adults ( 47 , 48 ) and adolescents ( 49 ). In the current study, the sub-dimension of attentional impulsivity correlated the most with suicide attempt history, in excess of subjects who fulfilled ADHD.…”

Section: Discussionmentioning

confidence: 99%

Symptoms characteristics of personality disorders associated with suicidal ideation and behaviors in a clinical sample of adolescents with a depressive disorder

Gifuni,

Spodenkiewicz,

Laurent

et al. 2023

Front. Psychiatry

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IntroductionPathological personality traits have repeatedly been identified as important risk factors for suicidal ideation and behaviors. Moreover, impulsive-aggressive traits, have shown a consistent association with suicidal behaviors across the lifespan. Adolescence represents a critical period for the emergence of different personality traits, mood disorders, and suicidal behaviors, but the relationship between these variables remain poorly understood.MethodsThese variables were examined in a cross-sectional case–control design involving three groups: 30 adolescents with a depressive disorder and past suicide attempt (Mean Age = 16.2, Females = 26), 38 adolescents with a depressive disorder but without past suicide attempt (Mean age = 16.0, Females = 29), and 34 healthy adolescent controls (Mean age = 15.2, Females = 22). Suicidal ideations were indexed using Suicidal Behavior Questionnaire (SBQ-R), psychiatric disorder assessed using a semi-structured questionnaire (K-SADS-PL), depressive symptoms with the Beck Depressive Inventory (BDI), symptoms characteristics of personality disorders with the Scheduled Clinical Interview for the DSM-IV (SCID-II) screening questionnaire, and impulsivity with the Barratt Impulsivesness Scale (BIS).ResultsFindings showed that impulsivity (F = 11.0, p < 0.0001) and antisocial symptoms characteristics of personality disorders (p < 0.001, d = 0.70) displayed the most robust association with adolescent suicide attempts. Borderline symptoms characteristics of personality disorders did not discriminate attempters from non-attempters but presented high correlations with suicidal ideation and depression severity. In an item-wise analysis, suicide attempt status was uniquely correlated with symptoms characteristics of an antisocial personality disorder. Suicide attempt status also correlated with non-suicidal self-injury and a chronic feeling of emptiness.DiscussionThe caveats of this cross-sectional study include the stability of symptoms characteristics of personality disorders in adolescence and the limited sample size. In sum, suicidal behaviors were characteristically correlated with increased impulsivity and antisocial symptoms characteristics of personality disorders, but other symptoms characteristics of personality disorders were relevant to adolescent depression and suicidal ideation. Understanding the emergence of symptoms characteristics of personality disorders and suicidal behaviors in a developmental context can ultimately inform not only the neurobiological origin of suicidal behaviors, but also provide new avenues for early detection and intervention.

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The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects

Cited by 9 publications

References 52 publications

Intra-Familial Adverse Childhood Experiences and Suicidal Behaviors among Tunisian Youth: The Mediating Effects of Impulsivity and Resilience

Intra-Familial Adverse Childhood Experiences and Suicidal Behaviors among Tunisian Youth: The Mediating Effects of Impulsivity and Resilience

Dissecting early life stress-induced adolescent depression through epigenomic approach

Symptoms characteristics of personality disorders associated with suicidal ideation and behaviors in a clinical sample of adolescents with a depressive disorder

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