2023
DOI: 10.1111/cdev.13972
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The mediation effect of glucocorticoid receptor gene (NR3C1) methylation between childhood maltreatment and depressive symptoms in Chinese adolescents: A 2‐year longitudinal study

Abstract: This three‐wave longitudinal study examined whether methylation alterations in promoter exon 1F of a stress‐related gene—NR3C1 (NR3C1‐1F)—explained the longitudinal associations between childhood maltreatment and adolescent depressive symptoms. A total of 370 Han Chinese adolescents (Mage = 16.31 ± 1.28 years; 51.4% girls) recruited from Shandong, China were tracked from 2018 to 2020. The results showed that the severity of childhood maltreatment, especially that of emotional abuse and physical neglect, confer… Show more

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